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- W1970133497 abstract "G-protein-coupled metabotropic glutamate group I receptors (mGluR1s) mediate synaptic transmission and plasticity in Purkinje cells and, therefore, critically determine cerebellar motor control and learning. Purkinje cells express two members of the G-protein G q family, namely G q and G 11 . Although in vitro coexpression of mGluR1 with either Gα 11 or Gα q produces equally well functioning signaling cascades, Gα q - and Gα 11 -deficient mice exhibit distinct alterations in motor coordination. By using whole-cell recordings and Ca 2+ imaging in Purkinje cells, we show that Gα q is required for mGluR-dependent synaptic transmission and for long-term depression (LTD). Gα 11 has no detectable contribution for synaptic transmission but also contributes to LTD. Quantitative single-cell RT-PCR analyses in Purkinje cells demonstrate a more than 10-fold stronger expression of Gα q versus Gα 11 . Our findings suggest an expression level-dependent action of Gα q and Gα 11 for Purkinje cell signaling and assign specific roles of these two G q isoforms for motor coordination." @default.
- W1970133497 created "2016-06-24" @default.
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- W1970133497 date "2004-06-02" @default.
- W1970133497 modified "2023-10-17" @default.
- W1970133497 title "Distinct Roles of Gα<sub>q</sub>and Gα<sub>11</sub>for Purkinje Cell Signaling and Motor Behavior" @default.
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- W1970133497 doi "https://doi.org/10.1523/jneurosci.4193-03.2004" @default.
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