FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970135497> ?p ?o ?g. }

• W1970135497 endingPage "179" @default.
• W1970135497 startingPage "168" @default.
• W1970135497 abstract "Previous work has shown that infusion of skin-derived precursors pre-differentiated into Schwann cells (SKP-SCs) can remyelinate injured and regenerating axons, and improve indices of axonal regeneration and electrophysiological parameters in rodents. We hypothesized that SKP-SC therapy would improve behavioral outcomes following nerve injury repair and tested this in a pre-clinical trial in 90 rats. A model of sciatic nerve injury and acellular graft repair was used to compare injected SKP-SCs to nerve-derived Schwann cells or media, and each was compared to the gold standard nerve isograft repair. In a second experiment, rats underwent right tibial nerve transection and received either acute or delayed direct nerve repair, with injections of either 1) SKP-SCs distal to the repair site, 2) carrier medium alone, or 3) dead SKP-SCs, and were followed for 4, 8 or 17 weeks. For delayed repairs, both transected nerve ends were capped and repaired 11 weeks later, along with injections of cells or media as above, and followed for 9 additional weeks (total of 20 weeks). Rats were serially tested for skilled locomotion and a slip ratio was calculated for the horizontal ladder-rung and tapered beam tasks. Immediately after nerve injury and with chronic denervation, slip ratios were dramatically elevated. In the GRAFT repair study, the SKP-SC treated rats showed statistically significant improvement in ladder rung as compared to all other groups, and exhibited the greatest similarity to the sham controls on the tapered beam by study termination. In the ACUTE repair arm, the SKP-SC group showed marked improvement in ladder rung slip ratio as early as 5 weeks after surgery, which was sustained for the duration of the experiment. Groups that received media and dead SKP-SCs improved with significantly slower progression. In the DELAYED repair arm, the SKP-SC group became significantly better than other groups 7 weeks after the repair, while the media and the dead SKP-SCs showed no significant improvement in slip ratios. On histomorphometrical analysis, SKP-SC group showed significantly increased mean axon counts while the percent myelin debris was significantly lower at both 4 and 8 weeks, suggesting that a less inhibitory micro-environment may have contributed to accelerated axonal regeneration. For delayed repair, mean axon counts were significantly higher in the SKP-SC group. Compound action potential amplitudes and muscle weights were also improved by cell therapy. In conclusion, SKP-SC therapy improves behavioral recovery after acute, chronic and nerve graft repair beyond the current standard of microsurgical nerve repair." @default.
• W1970135497 created "2016-06-24" @default.
• W1970135497 creator A5003102277 @default.
• W1970135497 creator A5011311146 @default.
• W1970135497 creator A5044927702 @default.
• W1970135497 creator A5053114491 @default.
• W1970135497 creator A5059474653 @default.
• W1970135497 creator A5061317490 @default.
• W1970135497 creator A5064113702 @default.
• W1970135497 creator A5068700510 @default.
• W1970135497 creator A5070755534 @default.
• W1970135497 creator A5087055719 @default.
• W1970135497 date "2014-04-01" @default.
• W1970135497 modified "2023-10-13" @default.
• W1970135497 title "Skin derived precursor Schwann cells improve behavioral recovery for acute and delayed nerve repair" @default.
• W1970135497 cites W129395966 @default.
• W1970135497 cites W1515977320 @default.
• W1970135497 cites W1556207275 @default.
• W1970135497 cites W1618653001 @default.
• W1970135497 cites W1680596716 @default.
• W1970135497 cites W1966702161 @default.
• W1970135497 cites W1970177659 @default.
• W1970135497 cites W1975409144 @default.
• W1970135497 cites W1977532998 @default.
• W1970135497 cites W1985265330 @default.
• W1970135497 cites W1985965749 @default.
• W1970135497 cites W1986351043 @default.
• W1970135497 cites W1987976939 @default.
• W1970135497 cites W1996153370 @default.
• W1970135497 cites W1996342572 @default.
• W1970135497 cites W2000596658 @default.
• W1970135497 cites W2002135687 @default.
• W1970135497 cites W2004990291 @default.
• W1970135497 cites W2005600057 @default.
• W1970135497 cites W2008431619 @default.
• W1970135497 cites W2009425656 @default.
• W1970135497 cites W2010853947 @default.
• W1970135497 cites W2015625647 @default.
• W1970135497 cites W2019730170 @default.
• W1970135497 cites W2023230379 @default.
• W1970135497 cites W2025681571 @default.
• W1970135497 cites W2030661572 @default.
• W1970135497 cites W2031190236 @default.
• W1970135497 cites W2031289707 @default.
• W1970135497 cites W2038708423 @default.
• W1970135497 cites W2044765320 @default.
• W1970135497 cites W2055343760 @default.
• W1970135497 cites W2056859189 @default.
• W1970135497 cites W2062822941 @default.
• W1970135497 cites W2066318475 @default.
• W1970135497 cites W2073484166 @default.
• W1970135497 cites W2077016325 @default.
• W1970135497 cites W2078952151 @default.
• W1970135497 cites W2080573727 @default.
• W1970135497 cites W2080916203 @default.
• W1970135497 cites W2081805576 @default.
• W1970135497 cites W2085776411 @default.
• W1970135497 cites W2086441579 @default.
• W1970135497 cites W2093229003 @default.
• W1970135497 cites W2096903993 @default.
• W1970135497 cites W2100528451 @default.
• W1970135497 cites W2115839995 @default.
• W1970135497 cites W2118503726 @default.
• W1970135497 cites W2141310245 @default.
• W1970135497 cites W2144902536 @default.
• W1970135497 cites W2155878786 @default.
• W1970135497 cites W2157281893 @default.
• W1970135497 cites W2158330548 @default.
• W1970135497 cites W2308860318 @default.
• W1970135497 cites W4243376484 @default.
• W1970135497 doi "https://doi.org/10.1016/j.expneurol.2014.01.002" @default.
• W1970135497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24440805" @default.
• W1970135497 hasPublicationYear "2014" @default.
• W1970135497 type Work @default.
• W1970135497 sameAs 1970135497 @default.
• W1970135497 citedByCount "77" @default.
• W1970135497 countsByYear W19701354972014 @default.
• W1970135497 countsByYear W19701354972015 @default.
• W1970135497 countsByYear W19701354972016 @default.
• W1970135497 countsByYear W19701354972017 @default.
• W1970135497 countsByYear W19701354972018 @default.
• W1970135497 countsByYear W19701354972019 @default.
• W1970135497 countsByYear W19701354972020 @default.
• W1970135497 countsByYear W19701354972021 @default.
• W1970135497 countsByYear W19701354972022 @default.
• W1970135497 countsByYear W19701354972023 @default.
• W1970135497 crossrefType "journal-article" @default.
• W1970135497 hasAuthorship W1970135497A5003102277 @default.
• W1970135497 hasAuthorship W1970135497A5011311146 @default.
• W1970135497 hasAuthorship W1970135497A5044927702 @default.
• W1970135497 hasAuthorship W1970135497A5053114491 @default.
• W1970135497 hasAuthorship W1970135497A5059474653 @default.
• W1970135497 hasAuthorship W1970135497A5061317490 @default.
• W1970135497 hasAuthorship W1970135497A5064113702 @default.
• W1970135497 hasAuthorship W1970135497A5068700510 @default.
• W1970135497 hasAuthorship W1970135497A5070755534 @default.
• W1970135497 hasAuthorship W1970135497A5087055719 @default.
• W1970135497 hasConcept C105702510 @default.

• next