Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970136699> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1970136699 endingPage "0" @default.
- W1970136699 startingPage "0" @default.
- W1970136699 abstract "Purpose Glaucoma surgery fails in 30% due to excessive scar formation of the constructed channel. Our group found that vascular endothelial growth factor (VEGF) is upregulated in the aqueous humor of glaucoma patients and postoperatively in a rabbit model for trabeculectomy, that VEGF stimulates fibroblast proliferation in vitro whereas bevacizumab can inhibit their growth, and that a single peroperative intracameral injection of bevacizumab improves the surgical outcome of trabeculectomy in a rabbit model. Based on these findings, we set up a clinical trial to study the potential of bevacizumab as an anti-scarring agent after trabeculectomy. Methods This is a prospective, randomized, placebo-controlled, double-blinded experimental study. The effect of peroperative administration of 50 µl of bevacizumab (25mg/ml) on intraocular pressure, bleb characteristics, as well as number of postoperative IOP-lowering medications and surgical interventions is investigated. Patients with primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG) who are scheduled for primary trabeculectomy are included. Results Inclusions started on April 2009 and are still ongoing. Based on a priori calculations we need to include 124 patients. We already included 97 patients, 54 of which are POAG and 43 are NTG patients. By the end of September the majority will have ended the study. The preliminary results of this group will be presented at EVER. Conclusion This study will provide evidence on effectiveness and safety of single administration of bevacizumab during trabeculectomy to reduce the risk of surgical failure, avoiding or reducing the need for long-term medication use or secondary surgical intervention." @default.
- W1970136699 created "2016-06-24" @default.
- W1970136699 creator A5042788630 @default.
- W1970136699 creator A5043917421 @default.
- W1970136699 creator A5058810568 @default.
- W1970136699 creator A5078355359 @default.
- W1970136699 date "2010-09-01" @default.
- W1970136699 modified "2023-10-16" @default.
- W1970136699 title "Can peroperative bevacizumab (AvastinTM) improve trabeculectomy outcome? A prospective, randomized, placebo-controlled study" @default.
- W1970136699 doi "https://doi.org/10.1111/j.1755-3768.2010.3153.x" @default.
- W1970136699 hasPublicationYear "2010" @default.
- W1970136699 type Work @default.
- W1970136699 sameAs 1970136699 @default.
- W1970136699 citedByCount "0" @default.
- W1970136699 crossrefType "journal-article" @default.
- W1970136699 hasAuthorship W1970136699A5042788630 @default.
- W1970136699 hasAuthorship W1970136699A5043917421 @default.
- W1970136699 hasAuthorship W1970136699A5058810568 @default.
- W1970136699 hasAuthorship W1970136699A5078355359 @default.
- W1970136699 hasConcept C118487528 @default.
- W1970136699 hasConcept C141071460 @default.
- W1970136699 hasConcept C142724271 @default.
- W1970136699 hasConcept C168563851 @default.
- W1970136699 hasConcept C188816634 @default.
- W1970136699 hasConcept C204787440 @default.
- W1970136699 hasConcept C27081682 @default.
- W1970136699 hasConcept C2776228307 @default.
- W1970136699 hasConcept C2776694085 @default.
- W1970136699 hasConcept C2776766258 @default.
- W1970136699 hasConcept C2777802072 @default.
- W1970136699 hasConcept C2777824320 @default.
- W1970136699 hasConcept C2778527774 @default.
- W1970136699 hasConcept C2781092963 @default.
- W1970136699 hasConcept C71924100 @default.
- W1970136699 hasConceptScore W1970136699C118487528 @default.
- W1970136699 hasConceptScore W1970136699C141071460 @default.
- W1970136699 hasConceptScore W1970136699C142724271 @default.
- W1970136699 hasConceptScore W1970136699C168563851 @default.
- W1970136699 hasConceptScore W1970136699C188816634 @default.
- W1970136699 hasConceptScore W1970136699C204787440 @default.
- W1970136699 hasConceptScore W1970136699C27081682 @default.
- W1970136699 hasConceptScore W1970136699C2776228307 @default.
- W1970136699 hasConceptScore W1970136699C2776694085 @default.
- W1970136699 hasConceptScore W1970136699C2776766258 @default.
- W1970136699 hasConceptScore W1970136699C2777802072 @default.
- W1970136699 hasConceptScore W1970136699C2777824320 @default.
- W1970136699 hasConceptScore W1970136699C2778527774 @default.
- W1970136699 hasConceptScore W1970136699C2781092963 @default.
- W1970136699 hasConceptScore W1970136699C71924100 @default.
- W1970136699 hasLocation W19701366991 @default.
- W1970136699 hasOpenAccess W1970136699 @default.
- W1970136699 hasPrimaryLocation W19701366991 @default.
- W1970136699 hasRelatedWork W2031732907 @default.
- W1970136699 hasRelatedWork W2068363936 @default.
- W1970136699 hasRelatedWork W2212041467 @default.
- W1970136699 hasRelatedWork W2347370477 @default.
- W1970136699 hasRelatedWork W2778096022 @default.
- W1970136699 hasRelatedWork W2890025874 @default.
- W1970136699 hasRelatedWork W3032154728 @default.
- W1970136699 hasRelatedWork W3094600621 @default.
- W1970136699 hasRelatedWork W4200314767 @default.
- W1970136699 hasRelatedWork W2247202974 @default.
- W1970136699 hasVolume "88" @default.
- W1970136699 isParatext "false" @default.
- W1970136699 isRetracted "false" @default.
- W1970136699 magId "1970136699" @default.
- W1970136699 workType "article" @default.