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- W1970156146 abstract "The identification of hepatitis C virus (HCV) using molecular methods in 1989 by Michael Houghton and his colleagues at the Chiron Corporation and the Centers for Disease Control was unprecedented because the virus had never been visualized, grown in cell culture, or detected serologically. Following this dramatic discovery, HCV has dominated the practice and literature of liver disease and virology, as evidenced by more than 1700 peer-reviewed manuscripts in the year 2002 alone. Now entering its second decade in the spotlight, HCV continues to fascinate and perplex physicians and investigators, whereas patients look forward to a definitive resolution of the clinical issue. Although considerable progress has been made in the understanding of the epidemiology, natural history, virology, and immunopathogenesis of HCV infection, many scientific questions remain in need of resolution. Although the results of antiviral therapy have improved tremendously, solutions still need to be found for a significant proportion of ‘‘difficult-to-treat’’ patients. This issue of the Clinics in Liver Disease reviews the most recent scientific advances in HCV, with contributions from a truly international group of investigators. The first two articles by Drs. Penin and Pawlotsky review the current understanding of molecular virology of HCV. Dr Penin’s article shows how structural analyses of HCV components provide an essential framework to understand the mechanisms of viral replication, identify novel targets for antiviral intervention, and develop new strategies to prevent and combat viral hepatitis. HCV genetic variability is developed in Dr Pawlotsky’s article, with special emphasis on its underlying mechanisms, and the epidemiologic, pathogenic, clinical, and therapeutic implications of HCV genotype and quasispecies diversity." @default.
- W1970156146 created "2016-06-24" @default.
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- W1970156146 date "2003-02-01" @default.
- W1970156146 modified "2023-10-18" @default.
- W1970156146 title "Scientific advances in hepatitis C virus" @default.
- W1970156146 doi "https://doi.org/10.1016/s1089-3261(02)00070-3" @default.
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