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• W1970159369 endingPage "213" @default.
• W1970159369 startingPage "189" @default.
• W1970159369 abstract "The human body possesses highly specialized cellular defense mechanisms that, when activated pathologically, can induce a number of immunologic disorders. For a normal cellular immune response, the following conditions must be fulfilled: (1) accumulation of white blood cells, (2) their diapedesis through the vessel walls of the inflammatory area affected by an injurious agent, and (3) normal cellular effector functions in the tissue. This cascade of inflammatory processes has recently been shown to be regulated by a group of molecules that are termed adhesion molecules and consist of three subfamilies: selectins, the immunoglobulin supergene family, and integrins. The cellular functions influenced by adhesion molecules include, among others, cytotoxic T-cell responses, CD4-dependent activation of B lymphocytes by T lymphocytes, activation of granulocytes and macrophages, phagocytosis of opsonized particles by monocytes, macrophages, and granulocytes, antigen-presenting function of macrophages, their antibody-dependent cytotoxicity, initiation of a respiratory burst by white blood cells, and activation of fibroblasts. Studies performed in recent years have shown that pathogenetically relevant changes in the expression and function of adhesion molecules are involved in a variety of pulmonary diseases. These changes include the accumulation and activation of alveolar macrophages in smokers, experimentally induced bronchial hyperreactivity in bronchial asthma, accumulation of eosinophils in allergic rhinitis, bleomycin-induced pulmonary fibrosis, binding of viruses and bacteria to respiratory mucosa, and various mechanisms of acute damage to pulmonary parenchyma. Though their role in tumor development is still unclear, adhesion molecules are obviously involved in determining the route and organotropism of metastases. Further studies of the function of adhesion molecules in pulmonary diseases will contribute to our understanding of the pathomechanisms of these diseases and, through the development of specific antibodies, may provide attractive new therapeutic approaches to problems for which treatment is not yet available." @default.
• W1970159369 created "2016-06-24" @default.
• W1970159369 creator A5026303511 @default.
• W1970159369 creator A5083814273 @default.
• W1970159369 date "1994-07-01" @default.
• W1970159369 modified "2023-10-13" @default.
• W1970159369 title "Adhesion molecules in lung diseases" @default.
• W1970159369 cites W1483915559 @default.
• W1970159369 cites W1483951869 @default.
• W1970159369 cites W1494810979 @default.
• W1970159369 cites W1512161015 @default.
• W1970159369 cites W1513691409 @default.
• W1970159369 cites W1516509805 @default.
• W1970159369 cites W1518199423 @default.
• W1970159369 cites W1550039558 @default.
• W1970159369 cites W1551183408 @default.
• W1970159369 cites W1572786395 @default.
• W1970159369 cites W1576833897 @default.
• W1970159369 cites W1577998113 @default.
• W1970159369 cites W1587762493 @default.
• W1970159369 cites W1594147583 @default.
• W1970159369 cites W1820868233 @default.
• W1970159369 cites W1831734000 @default.
• W1970159369 cites W183611856 @default.
• W1970159369 cites W1902716167 @default.
• W1970159369 cites W1924392373 @default.
• W1970159369 cites W1963722963 @default.
• W1970159369 cites W1965742429 @default.
• W1970159369 cites W1965972035 @default.
• W1970159369 cites W1966286149 @default.
• W1970159369 cites W1966748740 @default.
• W1970159369 cites W1968455941 @default.
• W1970159369 cites W1968864414 @default.
• W1970159369 cites W1970145958 @default.
• W1970159369 cites W1973443459 @default.
• W1970159369 cites W1974540875 @default.
• W1970159369 cites W1975081780 @default.
• W1970159369 cites W1975085668 @default.
• W1970159369 cites W1977723670 @default.
• W1970159369 cites W1978160288 @default.
• W1970159369 cites W1980700255 @default.
• W1970159369 cites W1980923306 @default.
• W1970159369 cites W1980982223 @default.
• W1970159369 cites W1981752846 @default.
• W1970159369 cites W1984400493 @default.
• W1970159369 cites W1984496140 @default.
• W1970159369 cites W1985413021 @default.
• W1970159369 cites W1986586541 @default.
• W1970159369 cites W1987568997 @default.
• W1970159369 cites W1988227673 @default.
• W1970159369 cites W1990167427 @default.
• W1970159369 cites W1991303831 @default.
• W1970159369 cites W1991312386 @default.
• W1970159369 cites W1992072758 @default.
• W1970159369 cites W1993558144 @default.
• W1970159369 cites W1994103391 @default.
• W1970159369 cites W1994672868 @default.
• W1970159369 cites W1996666125 @default.
• W1970159369 cites W1996862503 @default.
• W1970159369 cites W1997416575 @default.
• W1970159369 cites W2000384489 @default.
• W1970159369 cites W2002035638 @default.
• W1970159369 cites W2004370735 @default.
• W1970159369 cites W2006506188 @default.
• W1970159369 cites W2008323459 @default.
• W1970159369 cites W2008424602 @default.
• W1970159369 cites W2008515082 @default.
• W1970159369 cites W2009070048 @default.
• W1970159369 cites W2011207006 @default.
• W1970159369 cites W2011683133 @default.
• W1970159369 cites W2015037737 @default.
• W1970159369 cites W2016265158 @default.
• W1970159369 cites W2016871274 @default.
• W1970159369 cites W2018433707 @default.
• W1970159369 cites W2023155608 @default.
• W1970159369 cites W2026075546 @default.
• W1970159369 cites W2028418732 @default.
• W1970159369 cites W2029231027 @default.
• W1970159369 cites W2029285210 @default.
• W1970159369 cites W2029432061 @default.
• W1970159369 cites W2029908066 @default.
• W1970159369 cites W2031142145 @default.
• W1970159369 cites W2032371793 @default.
• W1970159369 cites W2032630218 @default.
• W1970159369 cites W2034991654 @default.
• W1970159369 cites W2036143502 @default.
• W1970159369 cites W2036145275 @default.
• W1970159369 cites W2037776391 @default.
• W1970159369 cites W2037835531 @default.
• W1970159369 cites W2039292788 @default.
• W1970159369 cites W2048059264 @default.
• W1970159369 cites W2054024745 @default.
• W1970159369 cites W2054370905 @default.
• W1970159369 cites W2056573320 @default.
• W1970159369 cites W2061820966 @default.
• W1970159369 cites W2061934161 @default.
• W1970159369 cites W2063613980 @default.
• W1970159369 cites W2065692062 @default.

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