Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970159404> ?p ?o ?g. }
- W1970159404 endingPage "334" @default.
- W1970159404 startingPage "324" @default.
- W1970159404 abstract "Multiple genetic and epigenetic events, including the aberrant expression and function of molecules regulating cell signaling, growth, survival, motility, angiogenesis, and cell cycle control, underlie the progressive acquisition of a malignant phenotype in squamous carcinomas of the head and neck (HNSCC). In this regard, there has been a recent explosion in our understanding on how extracellular components, cell surface molecules, and a myriad of intracellular proteins and second messenger systems interact with each other, and are organized in pathways and networks to control cellular and tissue functions and cell fate decisions. This emerging ability to understand the basic mechanism controlling inter- and intra-cellular communication has provided an unprecedented opportunity to understand how their dysregulation contributes to the growth and dissemination of human cancers. Here, we will discuss the emerging information on how the use of modern technologies, including gene array and proteomic studies, combined with the molecular dissection of aberrant signaling networks, including the EGFR, ras, NFκB, Stat, Wnt/β-catenin, TGF-β, and PI3K-AKT-mTOR signaling pathways, can help elucidate the molecular mechanisms underlying HNSCC progression. Ultimately, we can envision that this knowledge may provide tremendous opportunities for the diagnosis of premalignant squamous lesions, and for the development of novel molecular-targeted strategies for the prevention and treatment of HNSCC." @default.
- W1970159404 created "2016-06-24" @default.
- W1970159404 creator A5009328221 @default.
- W1970159404 creator A5030668464 @default.
- W1970159404 creator A5038753309 @default.
- W1970159404 creator A5041104174 @default.
- W1970159404 creator A5059504870 @default.
- W1970159404 creator A5063316429 @default.
- W1970159404 date "2009-04-01" @default.
- W1970159404 modified "2023-10-11" @default.
- W1970159404 title "Dysregulated molecular networks in head and neck carcinogenesis" @default.
- W1970159404 cites W115270203 @default.
- W1970159404 cites W1534571605 @default.
- W1970159404 cites W1558410330 @default.
- W1970159404 cites W1581824974 @default.
- W1970159404 cites W1766452247 @default.
- W1970159404 cites W1850326393 @default.
- W1970159404 cites W1889152575 @default.
- W1970159404 cites W1965262464 @default.
- W1970159404 cites W1967803088 @default.
- W1970159404 cites W1969390279 @default.
- W1970159404 cites W1969543424 @default.
- W1970159404 cites W1970179765 @default.
- W1970159404 cites W1972699527 @default.
- W1970159404 cites W1974582859 @default.
- W1970159404 cites W1976004034 @default.
- W1970159404 cites W1976263453 @default.
- W1970159404 cites W1977532256 @default.
- W1970159404 cites W1977651481 @default.
- W1970159404 cites W1980480652 @default.
- W1970159404 cites W1980727520 @default.
- W1970159404 cites W1980878904 @default.
- W1970159404 cites W1984205398 @default.
- W1970159404 cites W1984246346 @default.
- W1970159404 cites W1986311875 @default.
- W1970159404 cites W1986486340 @default.
- W1970159404 cites W1988924112 @default.
- W1970159404 cites W1988934983 @default.
- W1970159404 cites W1991060266 @default.
- W1970159404 cites W1992676863 @default.
- W1970159404 cites W1999330214 @default.
- W1970159404 cites W2000630926 @default.
- W1970159404 cites W2005145657 @default.
- W1970159404 cites W2005204942 @default.
- W1970159404 cites W2006058060 @default.
- W1970159404 cites W2011262927 @default.
- W1970159404 cites W2011578236 @default.
- W1970159404 cites W2012558233 @default.
- W1970159404 cites W2016503230 @default.
- W1970159404 cites W2016568386 @default.
- W1970159404 cites W2017882961 @default.
- W1970159404 cites W2020830322 @default.
- W1970159404 cites W2022305490 @default.
- W1970159404 cites W2024377014 @default.
- W1970159404 cites W2025504025 @default.
- W1970159404 cites W2026412061 @default.
- W1970159404 cites W2027731187 @default.
- W1970159404 cites W2027858199 @default.
- W1970159404 cites W2027872382 @default.
- W1970159404 cites W2028062404 @default.
- W1970159404 cites W2029253199 @default.
- W1970159404 cites W2029523063 @default.
- W1970159404 cites W2032777920 @default.
- W1970159404 cites W2034269086 @default.
- W1970159404 cites W2034375425 @default.
- W1970159404 cites W2034957772 @default.
- W1970159404 cites W2036254130 @default.
- W1970159404 cites W2037038224 @default.
- W1970159404 cites W2038809664 @default.
- W1970159404 cites W2039395669 @default.
- W1970159404 cites W2040319558 @default.
- W1970159404 cites W2043103956 @default.
- W1970159404 cites W2044991100 @default.
- W1970159404 cites W2047057570 @default.
- W1970159404 cites W2050980183 @default.
- W1970159404 cites W2051143564 @default.
- W1970159404 cites W2051703790 @default.
- W1970159404 cites W2055247678 @default.
- W1970159404 cites W2055878807 @default.
- W1970159404 cites W2056137479 @default.
- W1970159404 cites W2058452793 @default.
- W1970159404 cites W2060402899 @default.
- W1970159404 cites W2064810566 @default.
- W1970159404 cites W2065601509 @default.
- W1970159404 cites W2069146938 @default.
- W1970159404 cites W2069389640 @default.
- W1970159404 cites W2070440428 @default.
- W1970159404 cites W2070732456 @default.
- W1970159404 cites W2070903674 @default.
- W1970159404 cites W2071706477 @default.
- W1970159404 cites W2075308548 @default.
- W1970159404 cites W2077173862 @default.
- W1970159404 cites W2077902938 @default.
- W1970159404 cites W2078841246 @default.
- W1970159404 cites W2079715612 @default.
- W1970159404 cites W2079977894 @default.
- W1970159404 cites W2080918030 @default.
- W1970159404 cites W2081184407 @default.