FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970163482> ?p ?o ?g. }

• W1970163482 abstract "We assessed whether CSF biomarkers at baseline predict decline in cognitive functioning as measured by repeated neuropsychological tests for four cognitive domains in patients with subjective complaints. We included 132 patients with subjective complaints (i.e., cognitively normal elderly), who underwent lumbar puncture at baseline and had at least 2 neuropsychological evaluations from our memory clinic based Amsterdam Dementia Cohort. Average follow-up was 2±1 years and consisted of a median of 2 (range 2–7) neuropsychological evaluations. CSF biomarkers beta-amyloid (beta-amyloid 42), total tau (tau) and phosphorylated tau-181 (ptau) were (1) recoded into quintiles and (2) used to define NIA-AA stages of preclinical Alzheimer's disease (AD). Predictive value of CSF biomarkers was assessed using linear mixed models. Outcome measures were compound z-scores for memory, attention, executive functioning, language and global cognition. All analyses were adjusted for age, gender and education. Patients were 61±8 years old, 56 (42%) were female. Average baseline MMSE was 28.3±1.5. Overall, cognitive performance remained stable during follow-up, but there were trends for memory improvement and decline in language function over time (Table 1). As CSF beta-amyloid 42 and beta-amyloid 42/tau quintiles became more AD-like, patients showed increasingly more decline in memory, executive functioning and global cognitive functioning. No CSF biomarkers predicted change in language or attention. There were no relations between (p)tau and change in cognition. Results were comparable for NIA-AA preclinical stages: patients in stage 1 (only beta-amyloid 42 abnormal) and 2 (beta-amyloid 42 and tau abnormal) showed increasingly more cognitive decline (Table 1). Memory performance stood out in this analysis, because it was estimated to improve in patients with NIA-AA preclinical stage 0, while it declined in stage 1 and 2 CSF evidence of preclinical AD ¾ especially low beta-amyloid 42 concentrations ¾ in patients with subjective complaints predicts decline in cognitive performance over time. (Preclinical) cognitive decline encompasses more than memory alone; it is also evident for executive functioning and global cognitive functioning. Judging from these data, cognitive decline may remain subclinical for years. Two-year prognosis for patients without any evidence of underlying AD pathology on the other hand is very good." @default.
• W1970163482 created "2016-06-24" @default.
• W1970163482 creator A5015650951 @default.
• W1970163482 creator A5029875703 @default.
• W1970163482 creator A5039782136 @default.
• W1970163482 creator A5059735620 @default.
• W1970163482 creator A5071843220 @default.
• W1970163482 creator A5072165526 @default.
• W1970163482 creator A5075394738 @default.
• W1970163482 date "2013-07-01" @default.
• W1970163482 modified "2023-09-27" @default.
• W1970163482 title "O3-03-02: CSF biomarkers predict longitudinal decline in memory and executive functioning in patients with subjective complaints" @default.
• W1970163482 doi "https://doi.org/10.1016/j.jalz.2013.04.249" @default.
• W1970163482 hasPublicationYear "2013" @default.
• W1970163482 type Work @default.
• W1970163482 sameAs 1970163482 @default.
• W1970163482 citedByCount "0" @default.
• W1970163482 crossrefType "journal-article" @default.
• W1970163482 hasAuthorship W1970163482A5015650951 @default.
• W1970163482 hasAuthorship W1970163482A5029875703 @default.
• W1970163482 hasAuthorship W1970163482A5039782136 @default.
• W1970163482 hasAuthorship W1970163482A5059735620 @default.
• W1970163482 hasAuthorship W1970163482A5071843220 @default.
• W1970163482 hasAuthorship W1970163482A5072165526 @default.
• W1970163482 hasAuthorship W1970163482A5075394738 @default.
• W1970163482 hasConcept C118552586 @default.
• W1970163482 hasConcept C126322002 @default.
• W1970163482 hasConcept C134290984 @default.
• W1970163482 hasConcept C14216870 @default.
• W1970163482 hasConcept C142724271 @default.
• W1970163482 hasConcept C143998085 @default.
• W1970163482 hasConcept C15744967 @default.
• W1970163482 hasConcept C169900460 @default.
• W1970163482 hasConcept C185592680 @default.
• W1970163482 hasConcept C2775968953 @default.
• W1970163482 hasConcept C2776656118 @default.
• W1970163482 hasConcept C2777895361 @default.
• W1970163482 hasConcept C2779134260 @default.
• W1970163482 hasConcept C2779483572 @default.
• W1970163482 hasConcept C2779985164 @default.
• W1970163482 hasConcept C2781197716 @default.
• W1970163482 hasConcept C2984863031 @default.
• W1970163482 hasConcept C536788834 @default.
• W1970163482 hasConcept C55493867 @default.
• W1970163482 hasConcept C71924100 @default.
• W1970163482 hasConcept C72563966 @default.
• W1970163482 hasConceptScore W1970163482C118552586 @default.
• W1970163482 hasConceptScore W1970163482C126322002 @default.
• W1970163482 hasConceptScore W1970163482C134290984 @default.
• W1970163482 hasConceptScore W1970163482C14216870 @default.
• W1970163482 hasConceptScore W1970163482C142724271 @default.
• W1970163482 hasConceptScore W1970163482C143998085 @default.
• W1970163482 hasConceptScore W1970163482C15744967 @default.
• W1970163482 hasConceptScore W1970163482C169900460 @default.
• W1970163482 hasConceptScore W1970163482C185592680 @default.
• W1970163482 hasConceptScore W1970163482C2775968953 @default.
• W1970163482 hasConceptScore W1970163482C2776656118 @default.
• W1970163482 hasConceptScore W1970163482C2777895361 @default.
• W1970163482 hasConceptScore W1970163482C2779134260 @default.
• W1970163482 hasConceptScore W1970163482C2779483572 @default.
• W1970163482 hasConceptScore W1970163482C2779985164 @default.
• W1970163482 hasConceptScore W1970163482C2781197716 @default.
• W1970163482 hasConceptScore W1970163482C2984863031 @default.
• W1970163482 hasConceptScore W1970163482C536788834 @default.
• W1970163482 hasConceptScore W1970163482C55493867 @default.
• W1970163482 hasConceptScore W1970163482C71924100 @default.
• W1970163482 hasConceptScore W1970163482C72563966 @default.
• W1970163482 hasIssue "4S_Part_13" @default.
• W1970163482 hasLocation W19701634821 @default.
• W1970163482 hasOpenAccess W1970163482 @default.
• W1970163482 hasPrimaryLocation W19701634821 @default.
• W1970163482 hasRelatedWork W1584555730 @default.
• W1970163482 hasRelatedWork W1656313275 @default.
• W1970163482 hasRelatedWork W1980916013 @default.
• W1970163482 hasRelatedWork W1987981395 @default.
• W1970163482 hasRelatedWork W1999862757 @default.
• W1970163482 hasRelatedWork W2030245939 @default.
• W1970163482 hasRelatedWork W3106300884 @default.
• W1970163482 hasRelatedWork W3118877676 @default.
• W1970163482 hasRelatedWork W3211849399 @default.
• W1970163482 hasRelatedWork W4385709918 @default.
• W1970163482 hasVolume "9" @default.
• W1970163482 isParatext "false" @default.
• W1970163482 isRetracted "false" @default.
• W1970163482 magId "1970163482" @default.
• W1970163482 workType "article" @default.