FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970171132> ?p ?o ?g. }

• W1970171132 endingPage "402" @default.
• W1970171132 startingPage "392" @default.
• W1970171132 abstract "We developed a model of human urinary bladder cancer progression from in situ precursor lesions to invasive carcinoma using whole organ histologic and genetic mapping. The model represents a high-density and detailed analysis regarding allelic losses on chromosomes 4, 8, 9, 11, and 17 as revealed by testing of 234 samples obtained from five cystectomy specimens. The samples corresponded to microscopically identified intraurothelial precursor conditions ranging from dysplasia to carcinoma in situ and invasive cancer. The initial analysis of paired normal and tumor DNA samples disclosed allelic losses in 72 of 225 tested hypervariable DNA markers. Subsequent use of these markers on all mucosal samples revealed that 47 had alterations with a statistically significant relation to urothelial neoplasia. The allelic losses clustered in 33 distinct chromosomal regions, indicating the location of putative tumor suppressor genes involved in the development and progression of urinary bladder cancer. Some of the markers with statistically significant allelic losses mapped to the regions containing well-characterized tumor suppressor genes but many were located in previously unknown loci. The majority of statistically significant allelic losses (70%) occurred early in low-grade intraurothelial dysplasia, and some of them involved adjacent areas of morphologically normal mucosa preceding the development of microscopically recognizable precursor lesions. The remaining 30% of markers developed allelic losses in the later phases of urothelial neoplasia, implicating their involvement in progression to invasive disease. Markers exhibiting allelic losses in early phases of urothelial neoplasia could be used for detection of occult preclinical or even premicroscopic phases of urinary bladder cancer, whereas markers that showed allelic losses in the later phases of the process could serve as indicators of progression to invasive disease. The approach used in this study facilitates genome-wide modeling of cancer progression and provides important chromosomal landmarks for more specific studies of multistep urinary bladder carcinogenesis. Genes Chromosomes Cancer 27:392–402, 2000. © 2000 Wiley-Liss, Inc." @default.
• W1970171132 created "2016-06-24" @default.
• W1970171132 creator A5001409206 @default.
• W1970171132 creator A5020414083 @default.
• W1970171132 creator A5025147400 @default.
• W1970171132 creator A5027475930 @default.
• W1970171132 creator A5032534171 @default.
• W1970171132 creator A5048981189 @default.
• W1970171132 creator A5069116689 @default.
• W1970171132 date "2000-04-01" @default.
• W1970171132 modified "2023-10-16" @default.
• W1970171132 title "Genetic modeling of human urinary bladder carcinogenesis" @default.
• W1970171132 cites W1965265115 @default.
• W1970171132 cites W1976128207 @default.
• W1970171132 cites W1988558833 @default.
• W1970171132 cites W1990423774 @default.
• W1970171132 cites W2000052961 @default.
• W1970171132 cites W2022346160 @default.
• W1970171132 cites W2035326480 @default.
• W1970171132 cites W2059934507 @default.
• W1970171132 cites W2071126398 @default.
• W1970171132 cites W2076249181 @default.
• W1970171132 cites W2078735245 @default.
• W1970171132 cites W2093531978 @default.
• W1970171132 cites W2138178697 @default.
• W1970171132 cites W2152117679 @default.
• W1970171132 cites W2315914439 @default.
• W1970171132 cites W2320017053 @default.
• W1970171132 cites W2401330586 @default.
• W1970171132 cites W2592966818 @default.
• W1970171132 cites W4230779957 @default.
• W1970171132 cites W4249567557 @default.
• W1970171132 cites W4293547319 @default.
• W1970171132 cites W4376099565 @default.
• W1970171132 cites W84698736 @default.
• W1970171132 doi "https://doi.org/10.1002/(sici)1098-2264(200004)27:4<392::aid-gcc9>3.0.co;2-n" @default.
• W1970171132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10719370" @default.
• W1970171132 hasPublicationYear "2000" @default.
• W1970171132 type Work @default.
• W1970171132 sameAs 1970171132 @default.
• W1970171132 citedByCount "66" @default.
• W1970171132 countsByYear W19701711322014 @default.
• W1970171132 countsByYear W19701711322015 @default.
• W1970171132 countsByYear W19701711322016 @default.
• W1970171132 countsByYear W19701711322017 @default.
• W1970171132 countsByYear W19701711322018 @default.
• W1970171132 countsByYear W19701711322019 @default.
• W1970171132 countsByYear W19701711322020 @default.
• W1970171132 countsByYear W19701711322021 @default.
• W1970171132 countsByYear W19701711322022 @default.
• W1970171132 crossrefType "journal-article" @default.
• W1970171132 hasAuthorship W1970171132A5001409206 @default.
• W1970171132 hasAuthorship W1970171132A5020414083 @default.
• W1970171132 hasAuthorship W1970171132A5025147400 @default.
• W1970171132 hasAuthorship W1970171132A5027475930 @default.
• W1970171132 hasAuthorship W1970171132A5032534171 @default.
• W1970171132 hasAuthorship W1970171132A5048981189 @default.
• W1970171132 hasAuthorship W1970171132A5069116689 @default.
• W1970171132 hasConcept C104317684 @default.
• W1970171132 hasConcept C105702510 @default.
• W1970171132 hasConcept C121608353 @default.
• W1970171132 hasConcept C126322002 @default.
• W1970171132 hasConcept C142724271 @default.
• W1970171132 hasConcept C180754005 @default.
• W1970171132 hasConcept C2775894508 @default.
• W1970171132 hasConcept C2775910329 @default.
• W1970171132 hasConcept C2777661416 @default.
• W1970171132 hasConcept C2778264664 @default.
• W1970171132 hasConcept C2779256057 @default.
• W1970171132 hasConcept C2779762690 @default.
• W1970171132 hasConcept C2780352672 @default.
• W1970171132 hasConcept C502942594 @default.
• W1970171132 hasConcept C54355233 @default.
• W1970171132 hasConcept C555283112 @default.
• W1970171132 hasConcept C71924100 @default.
• W1970171132 hasConcept C77411442 @default.
• W1970171132 hasConcept C86803240 @default.
• W1970171132 hasConceptScore W1970171132C104317684 @default.
• W1970171132 hasConceptScore W1970171132C105702510 @default.
• W1970171132 hasConceptScore W1970171132C121608353 @default.
• W1970171132 hasConceptScore W1970171132C126322002 @default.
• W1970171132 hasConceptScore W1970171132C142724271 @default.
• W1970171132 hasConceptScore W1970171132C180754005 @default.
• W1970171132 hasConceptScore W1970171132C2775894508 @default.
• W1970171132 hasConceptScore W1970171132C2775910329 @default.
• W1970171132 hasConceptScore W1970171132C2777661416 @default.
• W1970171132 hasConceptScore W1970171132C2778264664 @default.
• W1970171132 hasConceptScore W1970171132C2779256057 @default.
• W1970171132 hasConceptScore W1970171132C2779762690 @default.
• W1970171132 hasConceptScore W1970171132C2780352672 @default.
• W1970171132 hasConceptScore W1970171132C502942594 @default.
• W1970171132 hasConceptScore W1970171132C54355233 @default.
• W1970171132 hasConceptScore W1970171132C555283112 @default.
• W1970171132 hasConceptScore W1970171132C71924100 @default.
• W1970171132 hasConceptScore W1970171132C77411442 @default.
• W1970171132 hasConceptScore W1970171132C86803240 @default.
• W1970171132 hasIssue "4" @default.
• W1970171132 hasLocation W19701711321 @default.

• next