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• W1970173313 abstract "High throughput screening of Staphylococcus aureus phenylalanyl tRNA synthetase (FRS) identified ethanolamine 1 as a sub-micromolar hit. Optimisation studies led to the enantiospecific lead 64, a single-figure nanomolar inhibitor. The inhibitor series shows selectivity with respect to the mammalian enzyme and the potential for broad spectrum bacterial FRS inhibition." @default.
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• W1970173313 date "2005-05-01" @default.
• W1970173313 modified "2023-09-23" @default.
• W1970173313 title "Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase" @default.
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• W1970173313 doi "https://doi.org/10.1016/j.bmcl.2005.03.003" @default.
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