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• W1970173446 abstract "Block copolymers have a potential utility as drug carriers. In order to study their in vivo fate, the biodegradable block copolymer poly(D,L- lactide ethylene oxide) (PLA/PEO) (Mw 5000/5000) with a p-methoxyphenyl moiety was radio labeled with 125 I. The copolymer was [ 125 I] iodinated in the organic medium by a chloramine T method. The labeling efficiency was about 5%, and the agent was freed from [ 125 I] iodide by dialysis. The tissue distribution of radioactivity was determined at 5 min, 1, 2 and 24 hrs after intravenous injection of male rats with 125 I-labeled copolymer in the dose 4.5–5.5 mg/kg. After administration of the labeled copolymer, a high concentration of radioactivity in the liver during the initial time intervals was found. At the subsequent intervals after dosing, an increase in 125 I activity in the bowels was determined. The distribution of radioactivity into inflamed areas was evaluated as well. The inflammatory-to-non-inflammatory muscle tissue ratios increased with time from 2.18 (5 min), 3.63 (1 h) to 3.68 (2 hrs); after 24 hrs, this ratio was significantly lower (1.70). The PLA/PEO copolymer exhibits along residence time in the blood stream and, therefore, it could be employed as a drug delivery system for inflammatory and cancer treatment." @default.
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• W1970173446 date "2002-07-01" @default.
• W1970173446 modified "2023-10-10" @default.
• W1970173446 title "125I-Labeled PLA/PEO Block Copolymer: Biodistribution Studies in Rats" @default.
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• W1970173446 doi "https://doi.org/10.1106/088391102027534" @default.
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