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- W1970174970 abstract "A novel series of benzenesulfonanilide derivatives of 11β-HSD1 inhibitors were identified via modification of the sulfonamide core of the arylsulfonylpiperazine lead structures. The synthesis, in vitro biological evaluation, and structure–activity relationship of these compounds are presented. Optimization of this series rapidly resulted in the discovery of compounds (S)-10 and (S)-23 (11β-HSD1 SPA IC50 = 1.8 and 1.4 nM, respectively)." @default.
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- W1970174970 date "2012-06-01" @default.
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- W1970174970 title "Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors" @default.
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- W1970174970 doi "https://doi.org/10.1016/j.bmcl.2012.04.005" @default.
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