Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970175008> ?p ?o ?g. }
- W1970175008 endingPage "783" @default.
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- W1970175008 abstract "11beta-hydroxysteroid dehydrogenase Type 1 (11HSD1) catalyses regeneration of active 11-hydroxy glucocorticoids from inactive 11-keto metabolites within target tissues. Inhibition of 11HSD1 has been proposed as a novel strategy to lower intracellular glucocorticoid concentrations, without affecting circulating glucocorticoid levels and their responsiveness to stress. Increased 11HSD1 activity may be pathogenic, for example, in adipose tissue in obesity. Experiments in transgenic mice and using prototype inhibitors in humans show benefits of 11HSD1 inhibition in liver, adipose and brain tissue in treating features of the metabolic syndrome and cognitive dysfunction with ageing. The clinical development of potent selective 11HSD1 inhibitors is now a high priority." @default.
- W1970175008 created "2016-06-24" @default.
- W1970175008 creator A5017724906 @default.
- W1970175008 creator A5064304317 @default.
- W1970175008 date "2003-12-01" @default.
- W1970175008 modified "2023-10-14" @default.
- W1970175008 title "11β-Hydroxysteroid dehydrogenase Type 1 as a novel therapeutic target in metabolic and neurodegenerative disease" @default.
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