FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970179972> ?p ?o ?g. }

• W1970179972 endingPage "393" @default.
• W1970179972 startingPage "377" @default.
• W1970179972 abstract "Toll/IL-1R domain-containing adaptor inducing interferon-ß (IFN-ß) factor (TRIF) is a key adaptor for Toll-like receptor (TLR) 3 and TLR4 signaling. Using a novel cDNA isolate encoding a TRIF protein with a 21-residue deletion (Δ160-181) from its amino-terminal half, we investigated the impact of this deletion on TRIF functions. Transfection studies consistently showed higher expression levels of the (Δ160-181) TRIF compared to wild-type (wt) TRIF, an effect unrelated to apoptosis, cell lines or plasmid amplification. Colocalization of wt and (Δ160-181) TRIF proteins led to a dramatic reduction of their respective expressions, suggesting that wt/(Δ160-181) TRIF heterocomplexes are targeted for degradation. We demonstrated that wt TRIF associates with tumor necrosis factor-a receptor-associated factor 3 (TRAF3) better than (Δ160-181) TRIF, culminating in its greater ubiquitination and proteolysis. This explains, in part, the differential expression levels of the two TRIF proteins. Despite higher expression levels in transfected cells, (Δ160-181) TRIF inefficiently transactivated the IFN pathway, whereas the nuclear factor-κB (NF-κB) pathway activation remained similar to that by wt TRIF. In coexpression studies, (Δ160-181) TRIF marginally contributed to the IFN pathway activation, but still enhanced NF-κB signaling with wt TRIF. Therefore, this 21 amino acid sequence is crucial for TRAF3 association, modulation of TRIF stability and activation of the IFN pathway." @default.
• W1970179972 created "2016-06-24" @default.
• W1970179972 creator A5007421026 @default.
• W1970179972 creator A5010198045 @default.
• W1970179972 creator A5022821458 @default.
• W1970179972 creator A5035996420 @default.
• W1970179972 creator A5048379858 @default.
• W1970179972 creator A5061205525 @default.
• W1970179972 creator A5082420788 @default.
• W1970179972 date "2014-01-01" @default.
• W1970179972 modified "2023-09-24" @default.
• W1970179972 title "A New Domain in the Toll/IL-1R Domain-Containing Adaptor Inducing Interferon-ß Factor Protein Amino Terminus Is Important for Tumor Necrosis Factor-a Receptor-Associated Factor 3 Association, Protein Stabilization and Interferon Signaling" @default.
• W1970179972 cites W1491749295 @default.
• W1970179972 cites W1504914687 @default.
• W1970179972 cites W1581857504 @default.
• W1970179972 cites W1588312796 @default.
• W1970179972 cites W1633097546 @default.
• W1970179972 cites W1964558259 @default.
• W1970179972 cites W1972327788 @default.
• W1970179972 cites W1972508857 @default.
• W1970179972 cites W1977416546 @default.
• W1970179972 cites W1980993114 @default.
• W1970179972 cites W1996120614 @default.
• W1970179972 cites W2003385732 @default.
• W1970179972 cites W2004064281 @default.
• W1970179972 cites W2013601771 @default.
• W1970179972 cites W2019234632 @default.
• W1970179972 cites W2024991882 @default.
• W1970179972 cites W2032634316 @default.
• W1970179972 cites W2039179842 @default.
• W1970179972 cites W2042433863 @default.
• W1970179972 cites W2042872424 @default.
• W1970179972 cites W2046608701 @default.
• W1970179972 cites W2048833964 @default.
• W1970179972 cites W2048997734 @default.
• W1970179972 cites W2049115723 @default.
• W1970179972 cites W2049874360 @default.
• W1970179972 cites W2050343782 @default.
• W1970179972 cites W2050437677 @default.
• W1970179972 cites W2050962647 @default.
• W1970179972 cites W2051026238 @default.
• W1970179972 cites W2064229941 @default.
• W1970179972 cites W2067678108 @default.
• W1970179972 cites W2069381771 @default.
• W1970179972 cites W2071162967 @default.
• W1970179972 cites W2077494922 @default.
• W1970179972 cites W2082890018 @default.
• W1970179972 cites W2098901296 @default.
• W1970179972 cites W2103681939 @default.
• W1970179972 cites W2109491705 @default.
• W1970179972 cites W2111922856 @default.
• W1970179972 cites W2112002812 @default.
• W1970179972 cites W2115185894 @default.
• W1970179972 cites W2116101489 @default.
• W1970179972 cites W2118663884 @default.
• W1970179972 cites W2130322182 @default.
• W1970179972 cites W2130421043 @default.
• W1970179972 cites W2144787399 @default.
• W1970179972 cites W2146739467 @default.
• W1970179972 cites W2146915650 @default.
• W1970179972 cites W2148387062 @default.
• W1970179972 cites W2155706758 @default.
• W1970179972 cites W2158426338 @default.
• W1970179972 cites W2163278196 @default.
• W1970179972 cites W2165042359 @default.
• W1970179972 cites W2166495096 @default.
• W1970179972 doi "https://doi.org/10.1159/000356408" @default.
• W1970179972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4058787" @default.
• W1970179972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24577058" @default.
• W1970179972 hasPublicationYear "2014" @default.
• W1970179972 type Work @default.
• W1970179972 sameAs 1970179972 @default.
• W1970179972 citedByCount "5" @default.
• W1970179972 countsByYear W19701799722015 @default.
• W1970179972 countsByYear W19701799722019 @default.
• W1970179972 countsByYear W19701799722020 @default.
• W1970179972 countsByYear W19701799722021 @default.
• W1970179972 countsByYear W19701799722022 @default.
• W1970179972 crossrefType "journal-article" @default.
• W1970179972 hasAuthorship W1970179972A5007421026 @default.
• W1970179972 hasAuthorship W1970179972A5010198045 @default.
• W1970179972 hasAuthorship W1970179972A5022821458 @default.
• W1970179972 hasAuthorship W1970179972A5035996420 @default.
• W1970179972 hasAuthorship W1970179972A5048379858 @default.
• W1970179972 hasAuthorship W1970179972A5061205525 @default.
• W1970179972 hasAuthorship W1970179972A5082420788 @default.
• W1970179972 hasBestOaLocation W19701799721 @default.
• W1970179972 hasConcept C136449434 @default.
• W1970179972 hasConcept C153911025 @default.
• W1970179972 hasConcept C170493617 @default.
• W1970179972 hasConcept C183786373 @default.
• W1970179972 hasConcept C190283241 @default.
• W1970179972 hasConcept C2776709828 @default.
• W1970179972 hasConcept C2779004061 @default.
• W1970179972 hasConcept C31573885 @default.
• W1970179972 hasConcept C43929388 @default.
• W1970179972 hasConcept C502942594 @default.
• W1970179972 hasConcept C55493867 @default.

• next