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- W1970182983 abstract "Abstract The endotoxic polysaccharide from Serratia marcescens , which induced hemorrhage and necrosis in mouse sarcoma 37, was inactivated in vitro by extracts of intact cells of rabbit liver. The inactivating potency was associated with the basic protein fraction which was isolated with the aid of charged derivatives of synthetic polyglucose. Macromolecular interaction of the cationic proteins with the anionic endotoxic polysaccharide was demonstrated by zone electrophoresis and metachromasia. Polyglucose sulfate, a stronger polyanion than the endotoxic polysaccharide itself, prevented the inactivation. Since it also restored the original tumor-damaging activity, it was concluded that inactivation was due to a reversible macromolecular interaction of the anionic endotoxic polysaccharide with the cationic liver cell proteins. Cationic derivatives of synthetic polyglucose also inactivated the endotoxin by a similar mechanism." @default.
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- W1970182983 date "1963-10-01" @default.
- W1970182983 modified "2023-09-25" @default.
- W1970182983 title "Reversible inactivation of an endotoxin by intracellular protein" @default.
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- W1970182983 doi "https://doi.org/10.1016/0006-2952(63)90087-x" @default.
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