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• W1970187790 endingPage "5302" @default.
• W1970187790 startingPage "5298" @default.
• W1970187790 abstract "Postsynaptic density (PSD) fractions were isolated from the cerebral cortices of control and kindled rats and assayed for glutamate and gamma-aminobutyric acid-binding capacities and for the Ca2+/calmodulin-dependent protein kinase. Glutamate binding was found to be increased by approximately 50% in the PSDs isolated from kindled rats as compared to controls; this increase was almost completely from an increase in Bmax; Kd decreased only slightly. Studies with inhibitors indicate that the receptors involved were of the N-methyl-D-aspartate and quisqualate types. PSDs isolated from control and kindled rats did not differ in gamma-aminobutyric acid or flunitrazepam binding. The in vitro autophosphorylation of the Ca2+/calmodulin-dependent protein kinase was depressed by 45-76% in PSDs isolated from kindled rats as compared to controls, with little change in amount of the kinase. Therefore, we infer that (i) the kindled state is associated with an increase in glutamate activation of postsynaptic sites, allowing Ca2+ to enter dendritic spines, (ii) a change has occurred in activity of the protein kinase, which is the major cerebral cortex PSD protein, and (iii) perhaps major alterations in the PSD are a concomitant to the long-lasting nature of the kindled state." @default.
• W1970187790 created "2016-06-24" @default.
• W1970187790 creator A5020649058 @default.
• W1970187790 creator A5022406158 @default.
• W1970187790 creator A5050271181 @default.
• W1970187790 creator A5083203431 @default.
• W1970187790 date "1990-07-01" @default.
• W1970187790 modified "2023-09-27" @default.
• W1970187790 title "Effect of septal kindling on glutamate binding and calcium/calmodulin-dependent phosphorylation in a postsynaptic density fraction isolated from rat cerebral cortex." @default.
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• W1970187790 doi "https://doi.org/10.1073/pnas.87.14.5298" @default.
• W1970187790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/54310" @default.
• W1970187790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2164674" @default.
• W1970187790 hasPublicationYear "1990" @default.
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