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• W1970188239 abstract "The synthesis of ecdysteroids by the lepidopteran prothoracic gland is regulated by a brain neuropeptide hormone, prothoracicotropic hormone (PTTH). In Manduca sexta glands, PTTH stimulates several events including Ca(2+) influx, Ca(2+)-dependent cAMP generation and the activation of several protein kinases. In the present study, the path by which PTTH stimulates extracellular signal-activated regulated kinase (ERK) phosphorylation was investigated using PTTH and second messenger analogs. The results indicate that Ca(2+)-dependent processes, other than cAMP generation, play the major role in PTTH stimulation of ERK phosphorylation in larval prothoracic glands, that cAMP-dependent events increase in importance during later development and that PTTH-stimulated ERK phosphorylation is highest in larval glands. The decline in PTTH-stimulated ERK phosphorylation associated with metamorphosis results from decreased ERK levels and an increased basal rate of ERK phosphorylation. The data suggest that the role or importance of components of the PTTH signal transduction cascade are not fixed and can change during development." @default.
• W1970188239 created "2016-06-24" @default.
• W1970188239 creator A5020125684 @default.
• W1970188239 creator A5057813286 @default.
• W1970188239 date "2003-07-01" @default.
• W1970188239 modified "2023-09-27" @default.
• W1970188239 title "Prothoracicotropic hormone stimulated extracellular signal-regulated kinase (ERK) activity: the changing roles of Ca2+- and cAMP-dependent mechanisms in the insect prothoracic glands during metamorphosis" @default.
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• W1970188239 doi "https://doi.org/10.1016/s0303-7207(03)00090-x" @default.
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