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• W1970190638 abstract "The present study was carried out in order to investigate the in vivo biotransformation and excretion of the flavone, tangeretin, found in citrus fruits, by analysing urine and faeces samples from rats after repeated administration of 100 mg/kg body weight/day tangeretin. The formed metabolites were separated and identified by HPLC and the structures elucidated by LC/MS and 1H NMR. Ten new, major metabolites with intact flavonoid structure were identified. The metabolites identified were either demethylated or hydroxylated derivatives of the parent compound and metabolic changes were found primarily to occur in the 4' position of the B-ring. The total urinary excretion of tangeretin metabolites with intact flavan nucleus was about 11% of the administered daily dose." @default.
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• W1970190638 date "2000-09-01" @default.
• W1970190638 modified "2023-09-25" @default.
• W1970190638 title "Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus" @default.
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• W1970190638 doi "https://doi.org/10.1016/s0278-6915(00)00072-7" @default.
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