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- W1970190670 abstract "The opioid growth factor (OGF)–OGF receptors (OGFr) axis plays an important role in the homeostasis and re-epithelialization of the mammalian cornea. This tonically active growth regulatory inhibitory pathway is involved in cell replication, and the endogenous neuropeptide OGF targets cyclin-dependent kinase inhibitors, p16 and/or p21. Blockade of OGF–OGFr interfacing by systemic or topical administration of opioid antagonists such as naltrexone (NTX) results in accelerated DNA synthesis, cell replication, and tissue repair. Molecular manipulation of OGFr using sense constructs delayed corneal re-epithelialization, whereas antisense constructs accelerated repair of the corneal surface. Corneal keratopathy, a significant complication of diabetes mellitus, is manifested by delays in corneal re-epithelialization following surgery, injury, or disease. Tissue culture studies have shown that addition of NTX stimulates DNA synthesis and explant outgrowth of rabbit corneal epithelium, whereas OGF depresses DNA synthesis and explant outgrowth in a receptor-mediated manner. NTX accelerated corneal re-epithelialization in organ cultures of human and rabbit cornea. Systemic application of NTX to the abraded corneas of rats, and topical administration of NTX to the injured rabbit ocular surface, increased re-epithelialization. Systemic injections or topical administration of NTX facilitates re-epithelialization of the cornea in diabetic rats. Given the vital role of the corneal epithelium in maintaining vision, the frequency of corneal complications related to diabetes (diabetic keratopathy), and the problems occurring in diabetic individuals postoperatively (e.g., vitrectomy), and that conventional therapies such as artificial tears and bandage contact lenses often fail, topical application of NTX merits clinical consideration." @default.
- W1970190670 created "2016-06-24" @default.
- W1970190670 creator A5020114822 @default.
- W1970190670 creator A5052671682 @default.
- W1970190670 creator A5059552811 @default.
- W1970190670 creator A5063088495 @default.
- W1970190670 date "2010-02-01" @default.
- W1970190670 modified "2023-10-06" @default.
- W1970190670 title "Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF)–OGF receptor (OGFr) axis with naltrexone: A review" @default.
- W1970190670 cites W150134369 @default.
- W1970190670 cites W1558236525 @default.
- W1970190670 cites W1849142001 @default.
- W1970190670 cites W1966976430 @default.
- W1970190670 cites W1968302298 @default.
- W1970190670 cites W1970119116 @default.
- W1970190670 cites W1972061655 @default.
- W1970190670 cites W1975892981 @default.
- W1970190670 cites W1976910497 @default.
- W1970190670 cites W1978618464 @default.
- W1970190670 cites W1978905100 @default.
- W1970190670 cites W1982004614 @default.
- W1970190670 cites W1982706451 @default.
- W1970190670 cites W1982971916 @default.
- W1970190670 cites W1983154408 @default.
- W1970190670 cites W1983464817 @default.
- W1970190670 cites W1985443081 @default.
- W1970190670 cites W1986890976 @default.
- W1970190670 cites W1994514488 @default.
- W1970190670 cites W1994875486 @default.
- W1970190670 cites W1995085365 @default.
- W1970190670 cites W1995391426 @default.
- W1970190670 cites W1996651764 @default.
- W1970190670 cites W1998484696 @default.
- W1970190670 cites W2001411670 @default.
- W1970190670 cites W2002744139 @default.
- W1970190670 cites W2003501490 @default.
- W1970190670 cites W2008914122 @default.
- W1970190670 cites W2010556990 @default.
- W1970190670 cites W2014662502 @default.
- W1970190670 cites W2018293430 @default.
- W1970190670 cites W2018885312 @default.
- W1970190670 cites W2019804349 @default.
- W1970190670 cites W2020910010 @default.
- W1970190670 cites W2022165992 @default.
- W1970190670 cites W2023399540 @default.
- W1970190670 cites W2025281085 @default.
- W1970190670 cites W2025860149 @default.
- W1970190670 cites W2025872886 @default.
- W1970190670 cites W2026094695 @default.
- W1970190670 cites W2026648348 @default.
- W1970190670 cites W2031809949 @default.
- W1970190670 cites W2036296920 @default.
- W1970190670 cites W2039927781 @default.
- W1970190670 cites W2041860756 @default.
- W1970190670 cites W2043541328 @default.
- W1970190670 cites W2044146419 @default.
- W1970190670 cites W2044615817 @default.
- W1970190670 cites W2045964960 @default.
- W1970190670 cites W2046150411 @default.
- W1970190670 cites W2046960568 @default.
- W1970190670 cites W2047912888 @default.
- W1970190670 cites W2049930866 @default.
- W1970190670 cites W2050631096 @default.
- W1970190670 cites W2050979966 @default.
- W1970190670 cites W2052695492 @default.
- W1970190670 cites W2052893860 @default.
- W1970190670 cites W2053542089 @default.
- W1970190670 cites W2059341589 @default.
- W1970190670 cites W2063761933 @default.
- W1970190670 cites W2066672219 @default.
- W1970190670 cites W2067141621 @default.
- W1970190670 cites W2073818402 @default.
- W1970190670 cites W2079697174 @default.
- W1970190670 cites W2081232623 @default.
- W1970190670 cites W2082940973 @default.
- W1970190670 cites W2086189744 @default.
- W1970190670 cites W2087797515 @default.
- W1970190670 cites W2088882122 @default.
- W1970190670 cites W2091428548 @default.
- W1970190670 cites W2093058381 @default.
- W1970190670 cites W2093749972 @default.
- W1970190670 cites W2094783777 @default.
- W1970190670 cites W2102303842 @default.
- W1970190670 cites W2102450673 @default.
- W1970190670 cites W2103347802 @default.
- W1970190670 cites W2109033229 @default.
- W1970190670 cites W2109257049 @default.
- W1970190670 cites W2113689119 @default.
- W1970190670 cites W2114596174 @default.
- W1970190670 cites W2115875384 @default.
- W1970190670 cites W2120630795 @default.
- W1970190670 cites W2125147357 @default.
- W1970190670 cites W2126701927 @default.
- W1970190670 cites W2127497521 @default.
- W1970190670 cites W2135841535 @default.
- W1970190670 cites W2140626566 @default.
- W1970190670 cites W2141880708 @default.
- W1970190670 cites W2141952686 @default.