FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970191747> ?p ?o ?g. }

• W1970191747 endingPage "1735" @default.
• W1970191747 startingPage "1731" @default.
• W1970191747 abstract "Lung cancer is known as the top cancer killer in most developed countries. However, there is currently no promising diagnostic or prognostic biomarker for lung cancer. This study aims to discover non-invasive differential markers in the serum of lung cancer patients, to determine the protein identity of the candidate biomarker(s), and to investigate any clinical implication of the biomarker(s) concerned. Blood specimens were collected from 154 pre-operative patients with lung cancer and 35 healthy blood donors with no evidence of lung cancer. Fractionated serum samples were processed by surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (MS). Candidate biomarker was identified using sodium dodecyl sulphate polyacrylamide gel electrophoresis and tryptic digestion followed by tandem MS fragmentation analysis, which was subsequently validated with immunoassay. A differential protein with m/z 11.6 kDa was detected and identified as an isoform of human serum amyloid A (SAA). It was significantly increased by 1822% in lung cancer patients when compared with the healthy controls, which gave an area under the receiver operator characteristic curve of 0.88. In addition, the protein was also significantly elevated by 77% in lung cancer patients with survival <5 years when compared with patients with survival ⩾5 years. There are several functions of the SAA protein, described in the context of inflammation, that are compatible with the mechanism of tumour invasion and metastasis. Our study not only detected increased SAA level in the serum of lung cancer patients but also identified that elevated SAA level may be a non-invasive biomarker useful for the prediction of lung cancer prognosis." @default.
• W1970191747 created "2016-06-24" @default.
• W1970191747 creator A5036119264 @default.
• W1970191747 creator A5036975956 @default.
• W1970191747 creator A5044561631 @default.
• W1970191747 creator A5082526653 @default.
• W1970191747 date "2010-05-25" @default.
• W1970191747 modified "2023-10-15" @default.
• W1970191747 title "Serum amyloid A is elevated in the serum of lung cancer patients with poor prognosis" @default.
• W1970191747 cites W2000600706 @default.
• W1970191747 cites W2009549731 @default.
• W1970191747 cites W2035189529 @default.
• W1970191747 cites W2046597088 @default.
• W1970191747 cites W2051924384 @default.
• W1970191747 cites W2058670939 @default.
• W1970191747 cites W2067839399 @default.
• W1970191747 cites W2076887271 @default.
• W1970191747 cites W2081178484 @default.
• W1970191747 cites W2082620667 @default.
• W1970191747 cites W2085009918 @default.
• W1970191747 cites W2093652821 @default.
• W1970191747 cites W2103726776 @default.
• W1970191747 cites W2108312665 @default.
• W1970191747 cites W2110046876 @default.
• W1970191747 cites W2129297473 @default.
• W1970191747 cites W2130559534 @default.
• W1970191747 cites W2134213739 @default.
• W1970191747 cites W2139663961 @default.
• W1970191747 cites W2143233121 @default.
• W1970191747 cites W2145627454 @default.
• W1970191747 cites W2154621549 @default.
• W1970191747 cites W2167409896 @default.
• W1970191747 cites W2256817328 @default.
• W1970191747 cites W2494474175 @default.
• W1970191747 cites W4233461824 @default.
• W1970191747 doi "https://doi.org/10.1038/sj.bjc.6605700" @default.
• W1970191747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2883701" @default.
• W1970191747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20502455" @default.
• W1970191747 hasPublicationYear "2010" @default.
• W1970191747 type Work @default.
• W1970191747 sameAs 1970191747 @default.
• W1970191747 citedByCount "81" @default.
• W1970191747 countsByYear W19701917472012 @default.
• W1970191747 countsByYear W19701917472013 @default.
• W1970191747 countsByYear W19701917472014 @default.
• W1970191747 countsByYear W19701917472015 @default.
• W1970191747 countsByYear W19701917472016 @default.
• W1970191747 countsByYear W19701917472017 @default.
• W1970191747 countsByYear W19701917472018 @default.
• W1970191747 countsByYear W19701917472019 @default.
• W1970191747 countsByYear W19701917472020 @default.
• W1970191747 countsByYear W19701917472021 @default.
• W1970191747 countsByYear W19701917472022 @default.
• W1970191747 countsByYear W19701917472023 @default.
• W1970191747 crossrefType "journal-article" @default.
• W1970191747 hasAuthorship W1970191747A5036119264 @default.
• W1970191747 hasAuthorship W1970191747A5036975956 @default.
• W1970191747 hasAuthorship W1970191747A5044561631 @default.
• W1970191747 hasAuthorship W1970191747A5082526653 @default.
• W1970191747 hasBestOaLocation W19701917471 @default.
• W1970191747 hasConcept C121608353 @default.
• W1970191747 hasConcept C126322002 @default.
• W1970191747 hasConcept C142724271 @default.
• W1970191747 hasConcept C143998085 @default.
• W1970191747 hasConcept C151730666 @default.
• W1970191747 hasConcept C2776256026 @default.
• W1970191747 hasConcept C2776914184 @default.
• W1970191747 hasConcept C2777714996 @default.
• W1970191747 hasConcept C2779013556 @default.
• W1970191747 hasConcept C2779343474 @default.
• W1970191747 hasConcept C2781197716 @default.
• W1970191747 hasConcept C55359608 @default.
• W1970191747 hasConcept C55493867 @default.
• W1970191747 hasConcept C71924100 @default.
• W1970191747 hasConcept C86803240 @default.
• W1970191747 hasConcept C90924648 @default.
• W1970191747 hasConceptScore W1970191747C121608353 @default.
• W1970191747 hasConceptScore W1970191747C126322002 @default.
• W1970191747 hasConceptScore W1970191747C142724271 @default.
• W1970191747 hasConceptScore W1970191747C143998085 @default.
• W1970191747 hasConceptScore W1970191747C151730666 @default.
• W1970191747 hasConceptScore W1970191747C2776256026 @default.
• W1970191747 hasConceptScore W1970191747C2776914184 @default.
• W1970191747 hasConceptScore W1970191747C2777714996 @default.
• W1970191747 hasConceptScore W1970191747C2779013556 @default.
• W1970191747 hasConceptScore W1970191747C2779343474 @default.
• W1970191747 hasConceptScore W1970191747C2781197716 @default.
• W1970191747 hasConceptScore W1970191747C55359608 @default.
• W1970191747 hasConceptScore W1970191747C55493867 @default.
• W1970191747 hasConceptScore W1970191747C71924100 @default.
• W1970191747 hasConceptScore W1970191747C86803240 @default.
• W1970191747 hasConceptScore W1970191747C90924648 @default.
• W1970191747 hasIssue "12" @default.
• W1970191747 hasLocation W19701917471 @default.
• W1970191747 hasLocation W19701917472 @default.
• W1970191747 hasLocation W19701917473 @default.
• W1970191747 hasLocation W19701917474 @default.
• W1970191747 hasOpenAccess W1970191747 @default.

• next