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- W1970193376 abstract "Bilateral infusions of colchicine or vehicle were made in the nucleus basalis magnocellularis of rats. Cortical homogenates were assessed in a choline acetyltransferase (ChAT) activity assay and a PC12 cell neurite outgrowth assay 3, 7, 14, 28, 35 or 84 days post-lesion. Cortical ChAT activity was initially decreased by 30%, followed by recovery to control levels at 84 days post-lesion. Cortical nerve growth factor (NGF) activity was increased 35% above control levels at all time points following colchicine infusion, while addition of a NGF antibody blocking all activity. The data show an increase in functional NGF in the target area of the lesioned neurons preceding and coinciding with regional recovery of a cholinergic marker, suggesting that NGF has a role in the cholinergic recovery." @default.
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- W1970193376 date "1997-08-01" @default.
- W1970193376 modified "2023-09-27" @default.
- W1970193376 title "Damage to the NBM leads to a sustained lesion-induced increase in functional NGF in the cortex" @default.
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- W1970193376 doi "https://doi.org/10.1097/00001756-199708180-00024" @default.
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