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• W1970195344 startingPage "89" @default.
• W1970195344 abstract "Neuroligins are postsynaptic neural cell adhesion molecules that mediate synaptic maturation and function in vertebrates and invertebrates, but their mechanisms of action and regulation are not well understood. At the Drosophila larval neuromuscular junction (NMJ), previous analysis demonstrated a requirement for Drosophila neuroligin 1 (dnlg1) in synaptic growth and maturation. The goal of the present study was to better understand the effects and mechanisms of loss-of-function and overexpression of dnlg1 on synapse size and function, and to identify signaling pathways that control dnlg1 expression. Consistent with reduced synapse size, evoked excitatory junctional currents (EJCs) were diminished in dnlg1 mutants but displayed normal Ca(2+) sensitivity and short-term plasticity. However, postsynaptic function was also perturbed, in that glutamate receptor staining and the distribution of amplitudes of miniature excitatory junctional currents (mEJCs) were abnormal in mutants. All the above phenotypes were rescued by a genomic transgene. Overexpression of dnlg1 in muscle resulted in synaptic overgrowth, but reduced the amplitudes of EJCs and mEJCs. Overgrowth and reduced EJC amplitude required Drosophila neurexin 1 (dnrx1) function, suggesting that increased DNlg1/DNrx1 signaling attenuates synaptic transmission and regulates growth through a retrograde mechanism. In contrast, reduced mEJC amplitude was independent of dnrx1. Synaptic overgrowth, triggered by neuronal hyperactivity, absence of the E3 ubiquitin ligase highwire, and increased phosphoinositide-3-kinase (PI3K) signaling in motor neurons reduced synaptic DNlg1 levels. Likewise, postsynaptic attenuation of PI3K, which increases synaptic strength, was associated with reduced DNlg1 levels. These observations suggest that activity and PI3K signaling pathways modulate growth and synaptic transmission through dnlg1-dependent mechanisms." @default.
• W1970195344 created "2016-06-24" @default.
• W1970195344 creator A5035628776 @default.
• W1970195344 creator A5090103186 @default.
• W1970195344 date "2012-11-01" @default.
• W1970195344 modified "2023-09-26" @default.
• W1970195344 title "Drosophila neuroligin 1 regulates synaptic growth and function in response to activity and phosphoinositide-3-kinase" @default.
• W1970195344 cites W1506710296 @default.
• W1970195344 cites W1592130608 @default.
• W1970195344 cites W1617352969 @default.
• W1970195344 cites W1919311176 @default.
• W1970195344 cites W1941436081 @default.
• W1970195344 cites W1963978693 @default.
• W1970195344 cites W1967233191 @default.
• W1970195344 cites W1988011192 @default.
• W1970195344 cites W1993415479 @default.
• W1970195344 cites W1993445706 @default.
• W1970195344 cites W1994528729 @default.
• W1970195344 cites W1995877423 @default.
• W1970195344 cites W1996092810 @default.
• W1970195344 cites W1997955557 @default.
• W1970195344 cites W2002025388 @default.
• W1970195344 cites W2005079627 @default.
• W1970195344 cites W2008461178 @default.
• W1970195344 cites W2013895597 @default.
• W1970195344 cites W2014255722 @default.
• W1970195344 cites W2015043293 @default.
• W1970195344 cites W2015556634 @default.
• W1970195344 cites W2022513417 @default.
• W1970195344 cites W2022963868 @default.
• W1970195344 cites W2023120898 @default.
• W1970195344 cites W2023179463 @default.
• W1970195344 cites W2028560526 @default.
• W1970195344 cites W2038872732 @default.
• W1970195344 cites W2046141144 @default.
• W1970195344 cites W2046165746 @default.
• W1970195344 cites W2046511552 @default.
• W1970195344 cites W2051426370 @default.
• W1970195344 cites W2051576463 @default.
• W1970195344 cites W2052112605 @default.
• W1970195344 cites W2052600995 @default.
• W1970195344 cites W2056422983 @default.
• W1970195344 cites W2057308155 @default.
• W1970195344 cites W2058473763 @default.
• W1970195344 cites W2064352628 @default.
• W1970195344 cites W2071216784 @default.
• W1970195344 cites W2072885702 @default.
• W1970195344 cites W2074258117 @default.
• W1970195344 cites W2075212318 @default.
• W1970195344 cites W2079684432 @default.
• W1970195344 cites W2082541370 @default.
• W1970195344 cites W2087967248 @default.
• W1970195344 cites W2088760718 @default.
• W1970195344 cites W2089756166 @default.
• W1970195344 cites W2090662268 @default.
• W1970195344 cites W2093807978 @default.
• W1970195344 cites W2096985729 @default.
• W1970195344 cites W2100135144 @default.
• W1970195344 cites W2100414555 @default.
• W1970195344 cites W2106951973 @default.
• W1970195344 cites W2109642486 @default.
• W1970195344 cites W2110643873 @default.
• W1970195344 cites W2111008646 @default.
• W1970195344 cites W2112927743 @default.
• W1970195344 cites W2117801156 @default.
• W1970195344 cites W2124894709 @default.
• W1970195344 cites W2125147395 @default.
• W1970195344 cites W2125524684 @default.
• W1970195344 cites W2126465155 @default.
• W1970195344 cites W2129585918 @default.
• W1970195344 cites W2130421403 @default.
• W1970195344 cites W2134236497 @default.
• W1970195344 cites W2135710940 @default.
• W1970195344 cites W2135843883 @default.
• W1970195344 cites W2137214779 @default.
• W1970195344 cites W2140551697 @default.
• W1970195344 cites W2147152912 @default.
• W1970195344 cites W2153492211 @default.
• W1970195344 cites W2153954651 @default.
• W1970195344 cites W2157215359 @default.
• W1970195344 cites W2160042818 @default.
• W1970195344 cites W2161597083 @default.
• W1970195344 cites W2163965551 @default.
• W1970195344 doi "https://doi.org/10.1016/j.mcn.2012.08.010" @default.
• W1970195344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3494790" @default.
• W1970195344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22954894" @default.
• W1970195344 hasPublicationYear "2012" @default.
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