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• W1970197446 abstract "High throughput screening of our small molecule combinatorial library identified a class of benzoylnaphthalenehydrazones with modest affinity for the human glucagon receptor. Optimization of this initial hit through a series of targeted libraries and traditional medicinal chemistry led to ligands with nanomolar affinities. Pharmacological evaluation demonstrated that these ligands were competitive glucagon receptor antagonists. Intravenous administration of a representative benzoylnaphthalenehydrazone into rats attenuated glucagon-stimulated glucose levels." @default.
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• W1970197446 date "2001-08-21" @default.
• W1970197446 modified "2023-09-27" @default.
• W1970197446 title "Identification of Alkylidene Hydrazides as Glucagon Receptor Antagonists" @default.
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• W1970197446 doi "https://doi.org/10.1021/jm000547o" @default.
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