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- W1970197667 abstract "Objective: Evidence suggests that female sexual dysfunction (FSD) is more prevalent in hypertensive women than in normotensive women. One possible explanationmight be the impacts of hypertension oxidative stress. The aim of this study was to evaluate the relationship between oxidative stress and FSD in hypertensivewomen.Methods:A total of 160 hypertensive (1 or 2 degree) women and 50 normotensivewomen, aged 18–60 years, were investigated. Hypertensive patients were newly diagnosed, previously untreated no less than one month. Female sexual function was evaluated using a female sexual function index (FSFI) questionnaire. Levels of serum 8-hydroxy-2′-deoxyguanosine (8-OHdG), 4-hydroxynonenal (HNE) and malondialdehyde (MDA) were measured. Linear regression analysis was used to identify predictors of an abnormal FSFI score with variables associated with it during univariate analysis. Results: Sexual dysfunction was found in 60.4% of hypertensive women compared with 26.0% of normotensive women (P=0.000). FSD rates gradually increased in older compared with younger hypertensive women. The mean score of FSFI at baseline decreased with age, and the between-age-group difference was statistically significant (P=0.000). Levels of 8-OHdG, HNE and MDA were lower in hypertensive patients compared with normotensive women (P=0.003, P=0.001, P=0.000, respectively). In hypertensive women, levels of 8-OHdG, HNE and MDA did not statistically differ between women with FSD and normal sexual function (P=0.375, P=0.452, P=0.378, respectively). No statistically significant correlationwas foundbetweenFSFI scoreandconcentrationof 8-OHdG, HNE and MDA (P=0.231, P=0.142, P=0.104, respectively). Serum 8-OHdG, HNE and MDA were not predictors of FSFI score. Conclusions: These results suggest that FSD ismore prevalent inwomen with essential hypertension compared with women with normal blood pressure. Status of oxidative stress is enhanced in hypertensive women. However, no relationship shows between FSD and oxidative stress. This topic needs to be explored in the future study." @default.
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- W1970197667 date "2011-10-01" @default.
- W1970197667 modified "2023-10-02" @default.
- W1970197667 title "The correlation between ambulatory blood pressure, carotid artery intima-media thickness and pulse wave velocity in prehypertensive subjects" @default.
- W1970197667 doi "https://doi.org/10.1016/j.ijcard.2011.08.490" @default.
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