Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970200029> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1970200029 endingPage "502" @default.
- W1970200029 startingPage "490" @default.
- W1970200029 abstract "The molecular mechanisms of the development of teratocarcinomas from stem cells are largely unknown. To determine which genes are associated with the transformation of these cells, we have performed oligonucleotide microarray analysis, using Affymetrix U74A GeneChips, on both cell cultures and tumors in nude mice. We identified 68 genes that significantly differed in expression between the ES cell culture and the teratocarcinoma cell line, SCC-PSA1, and 51 genes with statistically different expression patterns between the ES cell tumors and the teratocarcinomas (P < .00005). We found that there were 20 genes that had common expression patterns in both groups. We also examined the role of the transition from in vitro to in vivo by comparing ES cell culture to ES cell tumor, and teratocarcinoma cell line to teratocarcinomas. We identified 22 genes that were upregulated in the ES cell tumors and 42 that had a decreased expression in the tumor (P <.0001). In comparing SCC-PSA1 to its tumor, we identified 34 upregulated genes and 25 downregulated genes (P < .001). There were only 10 genes in common from these two lists. GenMapp search revealed that several pathways, especially the cell cycle pathway, are actively involved in the induction of teratocarcinomas. Our results indicate that many key development genes may play a key role in the transformation of ES cells into teratocarcinoma cells." @default.
- W1970200029 created "2016-06-24" @default.
- W1970200029 creator A5009548740 @default.
- W1970200029 creator A5041897903 @default.
- W1970200029 creator A5061594020 @default.
- W1970200029 date "2004-09-01" @default.
- W1970200029 modified "2023-10-16" @default.
- W1970200029 title "Gene Expression Profiling of Mouse Teratocarcinomas Uncovers Epigenetic Changes Associated with the Transformation of Mouse Embryonic Stem Cells" @default.
- W1970200029 cites W129461181 @default.
- W1970200029 cites W1967849546 @default.
- W1970200029 cites W1980335637 @default.
- W1970200029 cites W2021239799 @default.
- W1970200029 cites W2038437697 @default.
- W1970200029 cites W2049119567 @default.
- W1970200029 cites W2069271664 @default.
- W1970200029 cites W2072757555 @default.
- W1970200029 cites W2086454888 @default.
- W1970200029 cites W2093133947 @default.
- W1970200029 cites W2099135975 @default.
- W1970200029 cites W2139006568 @default.
- W1970200029 cites W2163438453 @default.
- W1970200029 cites W4247420482 @default.
- W1970200029 doi "https://doi.org/10.1593/neo.04124" @default.
- W1970200029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1531652" @default.
- W1970200029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15548357" @default.
- W1970200029 hasPublicationYear "2004" @default.
- W1970200029 type Work @default.
- W1970200029 sameAs 1970200029 @default.
- W1970200029 citedByCount "11" @default.
- W1970200029 countsByYear W19702000292012 @default.
- W1970200029 countsByYear W19702000292020 @default.
- W1970200029 crossrefType "journal-article" @default.
- W1970200029 hasAuthorship W1970200029A5009548740 @default.
- W1970200029 hasAuthorship W1970200029A5041897903 @default.
- W1970200029 hasAuthorship W1970200029A5061594020 @default.
- W1970200029 hasBestOaLocation W19702000291 @default.
- W1970200029 hasConcept C104317684 @default.
- W1970200029 hasConcept C145103041 @default.
- W1970200029 hasConcept C148738053 @default.
- W1970200029 hasConcept C1491633281 @default.
- W1970200029 hasConcept C150194340 @default.
- W1970200029 hasConcept C153911025 @default.
- W1970200029 hasConcept C18431079 @default.
- W1970200029 hasConcept C28328180 @default.
- W1970200029 hasConcept C2908788973 @default.
- W1970200029 hasConcept C41091548 @default.
- W1970200029 hasConcept C502942594 @default.
- W1970200029 hasConcept C54355233 @default.
- W1970200029 hasConcept C81885089 @default.
- W1970200029 hasConcept C8415881 @default.
- W1970200029 hasConcept C86803240 @default.
- W1970200029 hasConcept C95444343 @default.
- W1970200029 hasConceptScore W1970200029C104317684 @default.
- W1970200029 hasConceptScore W1970200029C145103041 @default.
- W1970200029 hasConceptScore W1970200029C148738053 @default.
- W1970200029 hasConceptScore W1970200029C1491633281 @default.
- W1970200029 hasConceptScore W1970200029C150194340 @default.
- W1970200029 hasConceptScore W1970200029C153911025 @default.
- W1970200029 hasConceptScore W1970200029C18431079 @default.
- W1970200029 hasConceptScore W1970200029C28328180 @default.
- W1970200029 hasConceptScore W1970200029C2908788973 @default.
- W1970200029 hasConceptScore W1970200029C41091548 @default.
- W1970200029 hasConceptScore W1970200029C502942594 @default.
- W1970200029 hasConceptScore W1970200029C54355233 @default.
- W1970200029 hasConceptScore W1970200029C81885089 @default.
- W1970200029 hasConceptScore W1970200029C8415881 @default.
- W1970200029 hasConceptScore W1970200029C86803240 @default.
- W1970200029 hasConceptScore W1970200029C95444343 @default.
- W1970200029 hasIssue "5" @default.
- W1970200029 hasLocation W19702000291 @default.
- W1970200029 hasLocation W19702000292 @default.
- W1970200029 hasLocation W19702000293 @default.
- W1970200029 hasLocation W19702000294 @default.
- W1970200029 hasOpenAccess W1970200029 @default.
- W1970200029 hasPrimaryLocation W19702000291 @default.
- W1970200029 hasRelatedWork W1531528770 @default.
- W1970200029 hasRelatedWork W1978835772 @default.
- W1970200029 hasRelatedWork W1983994322 @default.
- W1970200029 hasRelatedWork W2009519731 @default.
- W1970200029 hasRelatedWork W2015243007 @default.
- W1970200029 hasRelatedWork W2053053668 @default.
- W1970200029 hasRelatedWork W2053223017 @default.
- W1970200029 hasRelatedWork W2281526892 @default.
- W1970200029 hasRelatedWork W2415025170 @default.
- W1970200029 hasRelatedWork W2998765584 @default.
- W1970200029 hasVolume "6" @default.
- W1970200029 isParatext "false" @default.
- W1970200029 isRetracted "false" @default.
- W1970200029 magId "1970200029" @default.
- W1970200029 workType "article" @default.