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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970203467> ?p ?o ?g. }

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• W1970203467 abstract "Few therapeutic treatment options are available for patients suffering from metastatic androgen-independent prostate cancer. We investigated the ability of the estrogen metabolite 2-methoxyestradiol to inhibit the proliferation of a variety of human prostate cancer cell lines in vitro and to inhibit the growth of androgen-independent prostate cancer in a transgenic mouse model in vivo. Our results showed that 2-methoxyestradiol is a powerful growth inhibitor of LNCaP, DU 145, PC-3, and ALVA-31 prostate cancer cells. Cell flow cytometry of 2-methoxyestradiol-treated DU 145 cells showed a marked accumulation of cells in the G2/M phase of the cell cycle and an increase in the sub-G1 fraction (apoptotic). In addition, staining for annexin V, changes in nuclear morphology, and inhibition of caspase activity support a role for apoptosis. More importantly, we showed that 2-methoxyestradiol inhibits prostate tumor progression in the Ggamma/T-15 transgenic mouse model of androgen-independent prostate cancer without toxic side effects. These results in cell culture and an animal model support investigations into the clinical use of 2-methoxyestradiol in patients with androgen-independent prostate cancer." @default.
• W1970203467 created "2016-06-24" @default.
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• W1970203467 date "2001-08-01" @default.
• W1970203467 modified "2023-10-18" @default.
• W1970203467 title "2-Methoxyestradiol Induces G2/M Arrest and Apoptosis in Prostate Cancer" @default.
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• W1970203467 doi "https://doi.org/10.1006/bbrc.2001.5320" @default.
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