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- W1970224733 abstract "To assess the role of β-phenylethylamine in aspects of dopamine release, we measured the level of β-phenylethylamine in the rat striatum after killing the rats by microwave irradiation. We then investigated the effect of β-phenylethylamine on electrically evoked dopamine release from rat striatal slices in vitro. The striatal β-phenylethylamine level was 46.5±3.5 ng/g wet tissue, equivalent to 0.3 μmol/l. Superfusion with low concentrations of β-phenylethylamine up to 1 μmol/l had no effect on spontaneous or electrically evoked dopamine release from striatal slices. Quinpirole reduced the evoked dopamine release from slices in a concentration-dependent manner. The quinpirole-induced reduction of evoked dopamine release was attenuated 30% by superfusion with 0.3 μmol/l β-phenylethylamine. Moreover, the (−)-sulpiride (0.1 μmol/l)-induced increase in evoked dopamine release was also attenuated by superfusion with 0.3 μmol/l β-phenylethylamine. These data indicate that submicromolar levels of β-phenylethylamine could modify the dopamine autoreceptor mediated changes in evoked dopamine release from rat striatal slices." @default.
- W1970224733 created "2016-06-24" @default.
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- W1970224733 date "1998-02-01" @default.
- W1970224733 modified "2023-09-23" @default.
- W1970224733 title "Antagonistic effects of β-phenylethylamine on quinpirole- and (−)-sulpiride-induced changes in evoked dopamine release from rat striatal slices" @default.
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- W1970224733 doi "https://doi.org/10.1016/s0014-2999(97)01529-x" @default.
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