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• W1970230829 abstract "Aim & patients & methods: This study investigated 24-h pharmacokinetic and CYP3A5 pharmacogenetic differences between once-daily tacrolimus (Tac-q.d.) versus twice-daily tacrolimus (Tac-b.i.d.) pretransplantation and at 1 month and 1 year post-transplantaion. Results: The dose-adjusted trough level (C min ) and area under the blood concentration–time curve from 0 to 24 h (AUC 0–24 ) increased twofold within 1 year post-transplantation with both formulations and the two genotypes. Good correlations were observed between the AUC 0–24 and C min for both formulations. However, the dose-adjusted C min , but not dose-adjusted AUC 0–24 , was approximately 30% lower for Tac-q.d. than for Tac-b.i.d. Although the dose-adjusted C min was lower for Tac-q.d. than for Tac-b.i.d. in both genotypes, the dose-adjusted AUC 0–24 was approximately 25% lower for Tac-q.d. than for Tac-b.i.d. in CYP3A5 expressers, but not in nonexpressers during the study period. Conclusion: These results suggested that the approximately 30% lower C min for Tac-q.d. than for Tac-b.i.d. may have achieved the same AUC 0–24 with both formulations and may be associated with CYP3A5 pharmacogenomic differences, especially in CYP3A5 expressers, between Tac-b.i.d. and Tac-q.d. Original submitted 3 May 2013; Revision submitted 11 June 2014" @default.
• W1970230829 created "2016-06-24" @default.
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• W1970230829 date "2014-08-01" @default.
• W1970230829 modified "2023-09-27" @default.
• W1970230829 title "Pharmacokinetic and CYP3A5 pharmacogenetic differences between once- and twice-daily tacrolimus from the first dosing day to 1 year after renal transplantation" @default.
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• W1970230829 doi "https://doi.org/10.2217/pgs.14.98" @default.
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