FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970236259> ?p ?o ?g. }

• W1970236259 endingPage "614" @default.
• W1970236259 startingPage "604" @default.
• W1970236259 abstract "We report on the aggregation and dynamic behavior of excipients in type I and surfactant-free lipid formulations containing water-soluble cosolvents. Specifically we have investigated the internal structure of mixed glyceride formulations, with and without propylene glycol, in the anhydrous state and during dilution into water. We performed molecular dynamics (MD) simulations using GROMACS 3.1.4 (www.gromacs.org) to investigate the aggregation structures and phase changes which would occur on dispersion and dilution of the product in the gastrointestinal tract. MD experiments on mixed glyceride lipid formulations, revealed that they form microstructural features even in the presence of trace amounts of water, typical of what would be anticipated in capsule formulations in practice. These formulations are typically thought of as homogeneous mixtures, a view which has prevailed to some extent because the chemical diversity (chain length and degree of saturation) in excipients derived from vegetable oils prevents analysis of their microstructure by spectroscopic techniques. Our MD simulations suggest that a considerable depth of structure exists in the formulations, and that drugs partition into the various domains under the influence of intermolecular interactions, often dominated in the presence of water by hydrogen bonding. The lipid formulations consist of distinct regions of hydrophobic and hydrophilic character, essentially exhibiting reverse micellar character under low-water-content conditions. MD modeling has great potential as a predictive tool, in particular to identify drugs which may be prone to precipitation on dilution or dispersion of the lipid formulation." @default.
• W1970236259 created "2016-06-24" @default.
• W1970236259 creator A5027617278 @default.
• W1970236259 creator A5037277601 @default.
• W1970236259 creator A5064364780 @default.
• W1970236259 date "2009-03-23" @default.
• W1970236259 modified "2023-09-23" @default.
• W1970236259 title "Structure and Dynamics of Glyceride Lipid Formulations, with Propylene Glycol and Water" @default.
• W1970236259 cites W1491824558 @default.
• W1970236259 cites W1969076903 @default.
• W1970236259 cites W1978820401 @default.
• W1970236259 cites W1981021420 @default.
• W1970236259 cites W1984243815 @default.
• W1970236259 cites W1993835469 @default.
• W1970236259 cites W2000091385 @default.
• W1970236259 cites W2021060419 @default.
• W1970236259 cites W2021431226 @default.
• W1970236259 cites W2024384705 @default.
• W1970236259 cites W2026989650 @default.
• W1970236259 cites W2029667189 @default.
• W1970236259 cites W2035266068 @default.
• W1970236259 cites W2040468045 @default.
• W1970236259 cites W2041016731 @default.
• W1970236259 cites W2042834223 @default.
• W1970236259 cites W2046153515 @default.
• W1970236259 cites W2047327936 @default.
• W1970236259 cites W2051016884 @default.
• W1970236259 cites W2051046559 @default.
• W1970236259 cites W2056995570 @default.
• W1970236259 cites W2064324923 @default.
• W1970236259 cites W2069471467 @default.
• W1970236259 cites W2069506489 @default.
• W1970236259 cites W2070592894 @default.
• W1970236259 cites W2079495578 @default.
• W1970236259 cites W2080778237 @default.
• W1970236259 cites W2083008647 @default.
• W1970236259 cites W2103945336 @default.
• W1970236259 cites W2116493166 @default.
• W1970236259 cites W2123768693 @default.
• W1970236259 cites W2124347634 @default.
• W1970236259 cites W2127872066 @default.
• W1970236259 cites W2128572087 @default.
• W1970236259 cites W2128824543 @default.
• W1970236259 cites W2131223624 @default.
• W1970236259 cites W2146271266 @default.
• W1970236259 cites W2154986125 @default.
• W1970236259 cites W2156285632 @default.
• W1970236259 cites W2206309247 @default.
• W1970236259 cites W2440231639 @default.
• W1970236259 cites W3106452290 @default.
• W1970236259 doi "https://doi.org/10.1021/mp8001667" @default.
• W1970236259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19260675" @default.
• W1970236259 hasPublicationYear "2009" @default.
• W1970236259 type Work @default.
• W1970236259 sameAs 1970236259 @default.
• W1970236259 citedByCount "30" @default.
• W1970236259 countsByYear W19702362592012 @default.
• W1970236259 countsByYear W19702362592013 @default.
• W1970236259 countsByYear W19702362592014 @default.
• W1970236259 countsByYear W19702362592015 @default.
• W1970236259 countsByYear W19702362592016 @default.
• W1970236259 countsByYear W19702362592017 @default.
• W1970236259 countsByYear W19702362592018 @default.
• W1970236259 countsByYear W19702362592019 @default.
• W1970236259 countsByYear W19702362592020 @default.
• W1970236259 countsByYear W19702362592021 @default.
• W1970236259 countsByYear W19702362592023 @default.
• W1970236259 crossrefType "journal-article" @default.
• W1970236259 hasAuthorship W1970236259A5027617278 @default.
• W1970236259 hasAuthorship W1970236259A5037277601 @default.
• W1970236259 hasAuthorship W1970236259A5064364780 @default.
• W1970236259 hasConcept C112887158 @default.
• W1970236259 hasConcept C120665830 @default.
• W1970236259 hasConcept C121332964 @default.
• W1970236259 hasConcept C127413603 @default.
• W1970236259 hasConcept C147597530 @default.
• W1970236259 hasConcept C159467904 @default.
• W1970236259 hasConcept C166950319 @default.
• W1970236259 hasConcept C177562468 @default.
• W1970236259 hasConcept C178790620 @default.
• W1970236259 hasConcept C185592680 @default.
• W1970236259 hasConcept C192552737 @default.
• W1970236259 hasConcept C200514077 @default.
• W1970236259 hasConcept C32909587 @default.
• W1970236259 hasConcept C42360764 @default.
• W1970236259 hasConcept C43617362 @default.
• W1970236259 hasConcept C543025807 @default.
• W1970236259 hasConcept C55493867 @default.
• W1970236259 hasConcept C58226133 @default.
• W1970236259 hasConcept C59593255 @default.
• W1970236259 hasConcept C96618451 @default.
• W1970236259 hasConcept C97355855 @default.
• W1970236259 hasConceptScore W1970236259C112887158 @default.
• W1970236259 hasConceptScore W1970236259C120665830 @default.
• W1970236259 hasConceptScore W1970236259C121332964 @default.
• W1970236259 hasConceptScore W1970236259C127413603 @default.
• W1970236259 hasConceptScore W1970236259C147597530 @default.
• W1970236259 hasConceptScore W1970236259C159467904 @default.

• next