FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970238163> ?p ?o ?g. }

• W1970238163 endingPage "94" @default.
• W1970238163 startingPage "88" @default.
• W1970238163 abstract "Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus, causing severe central nerve system diseases without specific treatments. The NS2B-NS3 protease of flaviviruses mediates several cleavages on the flavivirus polyprotein, being believed to be a target for antiviral therapy. NS2B is the cofactor of the viral serine protease, correlating with stabilization and substrate recognition of the NS3 protease. In this study, we investigate the functional determinants in the JEV NS2B for the activation of the NS3 protease. Cis- and trans-cleavage assays of the deletions at the N-terminal of NS2B demonstrated that the NS2B residues Ser(46) to Ile(60) were the essential region required for both cis and trans activity of the NS3 protease. In addition, alanine substitution at the residues Trp53, Glu55, and Arg56 in NS2B significantly reduced the cis- and trans-cleavage activities of the NS3 protease. Sequence alignment and modeled structures suggested that functional determinants at the JEV NS2B residues Ser46 to Ile60, particularly in Trp53, Glu55 and Arg56 could play an important configuration required for the activity of the flavivirus NS3 protease. Our results might be useful for development of inhibitors that block the interaction between NS2B and NS3." @default.
• W1970238163 created "2016-06-24" @default.
• W1970238163 creator A5000238307 @default.
• W1970238163 creator A5032568029 @default.
• W1970238163 creator A5033776899 @default.
• W1970238163 creator A5045721425 @default.
• W1970238163 creator A5049036081 @default.
• W1970238163 creator A5056250854 @default.
• W1970238163 creator A5071469477 @default.
• W1970238163 creator A5075048093 @default.
• W1970238163 date "2007-07-01" @default.
• W1970238163 modified "2023-09-30" @default.
• W1970238163 title "Functional determinants of NS2B for activation of Japanese encephalitis virus NS3 protease" @default.
• W1970238163 cites W1865324159 @default.
• W1970238163 cites W1933943651 @default.
• W1970238163 cites W1985274927 @default.
• W1970238163 cites W1989503901 @default.
• W1970238163 cites W1993687095 @default.
• W1970238163 cites W2002185589 @default.
• W1970238163 cites W2009297402 @default.
• W1970238163 cites W2012761715 @default.
• W1970238163 cites W2023582466 @default.
• W1970238163 cites W2028064829 @default.
• W1970238163 cites W2030320182 @default.
• W1970238163 cites W2030439521 @default.
• W1970238163 cites W2030822571 @default.
• W1970238163 cites W2060148547 @default.
• W1970238163 cites W2078465579 @default.
• W1970238163 cites W2079949399 @default.
• W1970238163 cites W2101637508 @default.
• W1970238163 cites W2123102587 @default.
• W1970238163 cites W2142821747 @default.
• W1970238163 cites W2148230692 @default.
• W1970238163 cites W2150029541 @default.
• W1970238163 cites W2154101116 @default.
• W1970238163 doi "https://doi.org/10.1016/j.virusres.2007.03.022" @default.
• W1970238163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17467838" @default.
• W1970238163 hasPublicationYear "2007" @default.
• W1970238163 type Work @default.
• W1970238163 sameAs 1970238163 @default.
• W1970238163 citedByCount "20" @default.
• W1970238163 countsByYear W19702381632012 @default.
• W1970238163 countsByYear W19702381632013 @default.
• W1970238163 countsByYear W19702381632015 @default.
• W1970238163 countsByYear W19702381632017 @default.
• W1970238163 countsByYear W19702381632019 @default.
• W1970238163 countsByYear W19702381632021 @default.
• W1970238163 countsByYear W19702381632023 @default.
• W1970238163 crossrefType "journal-article" @default.
• W1970238163 hasAuthorship W1970238163A5000238307 @default.
• W1970238163 hasAuthorship W1970238163A5032568029 @default.
• W1970238163 hasAuthorship W1970238163A5033776899 @default.
• W1970238163 hasAuthorship W1970238163A5045721425 @default.
• W1970238163 hasAuthorship W1970238163A5049036081 @default.
• W1970238163 hasAuthorship W1970238163A5056250854 @default.
• W1970238163 hasAuthorship W1970238163A5071469477 @default.
• W1970238163 hasAuthorship W1970238163A5075048093 @default.
• W1970238163 hasConcept C132379496 @default.
• W1970238163 hasConcept C140704245 @default.
• W1970238163 hasConcept C159047783 @default.
• W1970238163 hasConcept C181199279 @default.
• W1970238163 hasConcept C2522874641 @default.
• W1970238163 hasConcept C2776408679 @default.
• W1970238163 hasConcept C2776714187 @default.
• W1970238163 hasConcept C2777510210 @default.
• W1970238163 hasConcept C2777807008 @default.
• W1970238163 hasConcept C2779141303 @default.
• W1970238163 hasConcept C2780568436 @default.
• W1970238163 hasConcept C55493867 @default.
• W1970238163 hasConcept C82553315 @default.
• W1970238163 hasConcept C83100098 @default.
• W1970238163 hasConcept C83455156 @default.
• W1970238163 hasConcept C86803240 @default.
• W1970238163 hasConceptScore W1970238163C132379496 @default.
• W1970238163 hasConceptScore W1970238163C140704245 @default.
• W1970238163 hasConceptScore W1970238163C159047783 @default.
• W1970238163 hasConceptScore W1970238163C181199279 @default.
• W1970238163 hasConceptScore W1970238163C2522874641 @default.
• W1970238163 hasConceptScore W1970238163C2776408679 @default.
• W1970238163 hasConceptScore W1970238163C2776714187 @default.
• W1970238163 hasConceptScore W1970238163C2777510210 @default.
• W1970238163 hasConceptScore W1970238163C2777807008 @default.
• W1970238163 hasConceptScore W1970238163C2779141303 @default.
• W1970238163 hasConceptScore W1970238163C2780568436 @default.
• W1970238163 hasConceptScore W1970238163C55493867 @default.
• W1970238163 hasConceptScore W1970238163C82553315 @default.
• W1970238163 hasConceptScore W1970238163C83100098 @default.
• W1970238163 hasConceptScore W1970238163C83455156 @default.
• W1970238163 hasConceptScore W1970238163C86803240 @default.
• W1970238163 hasIssue "1" @default.
• W1970238163 hasLocation W19702381631 @default.
• W1970238163 hasLocation W19702381632 @default.
• W1970238163 hasOpenAccess W1970238163 @default.
• W1970238163 hasPrimaryLocation W19702381631 @default.
• W1970238163 hasRelatedWork W1970238163 @default.
• W1970238163 hasRelatedWork W2032176260 @default.
• W1970238163 hasRelatedWork W2094230406 @default.
• W1970238163 hasRelatedWork W2111868491 @default.

• next