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- W1970258238 abstract "This report described that a hapten of racemic phosphonate 3 designed as the mimic of the transition state of hydrolysis of naproxen ethyl ester was successfully synthesized from easily available 2-acetyl-6-methoxy-naphthalene 5. Then BALB/C mice were immunized and one of the monoclonal catalytic antibodies, N116-27, which enantioselectively accelerated the hydrolysis of the R-(-)-naproxen ethyl ester was given. The Michaelis-Menton parameter for the catalyzed reaction was K(M)=6.67 mM and k(cat)/k(uncat)=5.8 x 10(4). This enantioselective result was explained by the fact that the R-isomer of rac-hapten was more immunogenic than the S-isomer." @default.
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- W1970258238 date "2002-07-01" @default.
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- W1970258238 title "Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies" @default.
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- W1970258238 doi "https://doi.org/10.1016/s0968-0896(02)00074-3" @default.
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