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• W1970260565 abstract "Cells from 13 cases of T-prolymphocytic leukaemia (T-PLL) were studied with a battery of immunological techniques in order to define their membrane phenotype. All cases were E-rosette positive and were negative with OKT6, anti-HLA-DR, anti-Ig and M-rosettes; in 3, 20–30% of the cells had receptors for C3b. 7 cases had predominantly a ‘helper/inducer’ T-subset phenotype, (OKT4+, OKT8-) and 4 had a ‘suppressor/cytotoxic’ phenotype (OKT8+, OKT4-). Cells in 2 cases coexpressed OKT4 and OKT8 in 48% and 95% of prolymphocytes and in another, both OKT4 and OKT8 were negative. Terminal transferase (TdT) was negative by IF in all the cases, but a low positive level was detected biochemically in one. Although T-PLL appears to be heterogenous in respect of membrane phenotype, the observation of unexpected features in 8 of the cases raises the possibility that it may originate in a cell of intermediate maturation between late thymocytes and mature T-lymphocytes. These features plus the clinical manifestation of the disease — typical morphology, splenomegaly, lymphadenopathy, skin lesions, high WBC and aggressive clinical course — help define T-PLL as a distinct clinicopathological entity." @default.
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• W1970260565 date "2009-04-24" @default.
• W1970260565 modified "2023-09-26" @default.
• W1970260565 title "The Membrane Phenotype of T-Prolymphocytic Leukaemia" @default.
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• W1970260565 doi "https://doi.org/10.1111/j.1600-0609.1982.tb00614.x" @default.
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