FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970261260> ?p ?o ?g. }

• W1970261260 endingPage "148" @default.
• W1970261260 startingPage "139" @default.
• W1970261260 abstract "Because of the inherent complexity of biological systems, there is often a choice between a number of apparently equally applicable physiologically based models to describe uptake and metabolism processes in toxicology or risk assessment. These models may fit the particular data sets of interest equally well, but may give quite different parameter estimates or predictions under different (extrapolated) conditions. Such competing models can be discriminated by a number of methods, including potential refutation by means of strategic experiments, and their ability to suitably incorporate all relevant physiological processes. For illustration, three currently used models for steady-state hepatic elimination--the venous equilibration model, the parallel tube model, and the distributed sinusoidal perfusion model--are reviewed and compared with particular reference to their application in the area of risk assessment. The ability of each of the models to describe and incorporate such physiological processes as protein binding, precursor-metabolite relations and hepatic zones of elimination, capillary recruitment, capillary heterogeneity, and intrahepatic shunting is discussed. Differences between the models in hepatic parameter estimation, extrapolation to different conditions, and interspecies scaling are discussed, and criteria for choosing one model over the others are presented. In this case, the distributed model provides the most general framework for describing physiological processes taking place in the liver, and has so far not been experimentally refuted, as have the other two models. These simpler models may, however, provide useful bounds on parameter estimates and on extrapolations and risk assessments." @default.
• W1970261260 created "2016-06-24" @default.
• W1970261260 creator A5027567493 @default.
• W1970261260 date "1992-03-01" @default.
• W1970261260 modified "2023-10-09" @default.
• W1970261260 title "Physiologically Based Liver Modeling and Risk Assessment" @default.
• W1970261260 cites W1724916994 @default.
• W1970261260 cites W1791458201 @default.
• W1970261260 cites W1799827520 @default.
• W1970261260 cites W195302871 @default.
• W1970261260 cites W1964634427 @default.
• W1970261260 cites W1977847200 @default.
• W1970261260 cites W1979364187 @default.
• W1970261260 cites W1982755239 @default.
• W1970261260 cites W1984813776 @default.
• W1970261260 cites W1999235175 @default.
• W1970261260 cites W1999557959 @default.
• W1970261260 cites W2000646754 @default.
• W1970261260 cites W2012531784 @default.
• W1970261260 cites W2014560565 @default.
• W1970261260 cites W2016812290 @default.
• W1970261260 cites W2021517264 @default.
• W1970261260 cites W2028573860 @default.
• W1970261260 cites W2034972002 @default.
• W1970261260 cites W2041690369 @default.
• W1970261260 cites W2041791869 @default.
• W1970261260 cites W2059656737 @default.
• W1970261260 cites W2059973305 @default.
• W1970261260 cites W2061384545 @default.
• W1970261260 cites W2070611009 @default.
• W1970261260 cites W2074352820 @default.
• W1970261260 cites W2082915842 @default.
• W1970261260 cites W2093159791 @default.
• W1970261260 cites W2148415180 @default.
• W1970261260 cites W2162606388 @default.
• W1970261260 cites W2273793512 @default.
• W1970261260 cites W2291459515 @default.
• W1970261260 cites W2327592647 @default.
• W1970261260 cites W2092908067 @default.
• W1970261260 doi "https://doi.org/10.1111/j.1539-6924.1992.tb01317.x" @default.
• W1970261260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1574613" @default.
• W1970261260 hasPublicationYear "1992" @default.
• W1970261260 type Work @default.
• W1970261260 sameAs 1970261260 @default.
• W1970261260 citedByCount "5" @default.
• W1970261260 countsByYear W19702612602012 @default.
• W1970261260 countsByYear W19702612602018 @default.
• W1970261260 crossrefType "journal-article" @default.
• W1970261260 hasAuthorship W1970261260A5027567493 @default.
• W1970261260 hasConcept C105795698 @default.
• W1970261260 hasConcept C132459708 @default.
• W1970261260 hasConcept C149782125 @default.
• W1970261260 hasConcept C186060115 @default.
• W1970261260 hasConcept C2524010 @default.
• W1970261260 hasConcept C33923547 @default.
• W1970261260 hasConcept C41008148 @default.
• W1970261260 hasConcept C76969082 @default.
• W1970261260 hasConcept C86803240 @default.
• W1970261260 hasConcept C99844830 @default.
• W1970261260 hasConceptScore W1970261260C105795698 @default.
• W1970261260 hasConceptScore W1970261260C132459708 @default.
• W1970261260 hasConceptScore W1970261260C149782125 @default.
• W1970261260 hasConceptScore W1970261260C186060115 @default.
• W1970261260 hasConceptScore W1970261260C2524010 @default.
• W1970261260 hasConceptScore W1970261260C33923547 @default.
• W1970261260 hasConceptScore W1970261260C41008148 @default.
• W1970261260 hasConceptScore W1970261260C76969082 @default.
• W1970261260 hasConceptScore W1970261260C86803240 @default.
• W1970261260 hasConceptScore W1970261260C99844830 @default.
• W1970261260 hasIssue "1" @default.
• W1970261260 hasLocation W19702612601 @default.
• W1970261260 hasLocation W19702612602 @default.
• W1970261260 hasOpenAccess W1970261260 @default.
• W1970261260 hasPrimaryLocation W19702612601 @default.
• W1970261260 hasRelatedWork W1960072520 @default.
• W1970261260 hasRelatedWork W1965029248 @default.
• W1970261260 hasRelatedWork W2023776155 @default.
• W1970261260 hasRelatedWork W2042397106 @default.
• W1970261260 hasRelatedWork W2220129715 @default.
• W1970261260 hasRelatedWork W2333625343 @default.
• W1970261260 hasRelatedWork W2387596242 @default.
• W1970261260 hasRelatedWork W2786502182 @default.
• W1970261260 hasRelatedWork W4296478327 @default.
• W1970261260 hasRelatedWork W4361730764 @default.
• W1970261260 hasVolume "12" @default.
• W1970261260 isParatext "false" @default.
• W1970261260 isRetracted "false" @default.
• W1970261260 magId "1970261260" @default.
• W1970261260 workType "article" @default.