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• W1970262783 startingPage "e13084" @default.
• W1970262783 abstract "The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention. We use genetic reporters to demonstrate activation of the unfolded protein response in a transgenic Drosophila model of Alzheimer's disease and related tauopathies. We then use loss of function genetic reagents to support a role for the unfolded protein response in protecting from tau neurotoxicity. Our findings suggest that the unfolded protein response can ameliorate the toxicity of tau in vivo." @default.
• W1970262783 created "2016-06-24" @default.
• W1970262783 creator A5002571663 @default.
• W1970262783 creator A5007366570 @default.
• W1970262783 date "2010-09-29" @default.
• W1970262783 modified "2023-10-18" @default.
• W1970262783 title "The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo" @default.
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• W1970262783 doi "https://doi.org/10.1371/journal.pone.0013084" @default.
• W1970262783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2947516" @default.
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