Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970282892> ?p ?o ?g. }
- W1970282892 endingPage "123" @default.
- W1970282892 startingPage "116" @default.
- W1970282892 abstract "Hemin-binding protein 35 (HBP35) may be an essential protein for bacterial survival in evasion from environmental stress in Porphyromonas gingivalis. The anti-recombinant HBP35 antibody inhibits P. gingivalis hemagglutination. This study considered the role of this protein for hemagglutination and adherence to host cells using the HBP35-deficient mutant (MD774) derived from P. gingivalis FDC381. FDC381 had strong hemagglutination activity, whereas MD774 had no activity. Anti-130-kDa hemagglutinin antibody, mAb-Pg-vc, reacted mainly with the 43- and 49-kDa molecules in the membrane fraction. However, no proteins reacted in the MD774. The hemolytic activity in MD774 was much lower than that in FDC381. Anti-recombinant HBP35 antibody strongly inhibited the P. gingivalis FDC381 adherence to epithelial cells. In addition, MD774 exhibited a significant decrease in the adherence. The hydrophobicity of MD774 was equal to 19.4% of that of FDC381. SDS-PAGE profiling of the membrane fractions of both strains showed very different profiles. Taken together, these findings suggest that HBP35 plays a role, not only in hemin-binding, but also in multiple P. gingivalis binding to erythrocytes, and host epithelial gingival cells. In addition, this protein may directly and/or indirectly affect the virulence of this organism." @default.
- W1970282892 created "2016-06-24" @default.
- W1970282892 creator A5006615953 @default.
- W1970282892 creator A5007480024 @default.
- W1970282892 creator A5027754047 @default.
- W1970282892 date "2010-03-01" @default.
- W1970282892 modified "2023-09-24" @default.
- W1970282892 title "Hemin-binding protein 35 (HBP35) plays an important role in bacteria–mammalian cells interactions in Porphyromonas gingivalis" @default.
- W1970282892 cites W1500570195 @default.
- W1970282892 cites W1511696771 @default.
- W1970282892 cites W1918611745 @default.
- W1970282892 cites W1931391884 @default.
- W1970282892 cites W1941891077 @default.
- W1970282892 cites W1958622927 @default.
- W1970282892 cites W1960068786 @default.
- W1970282892 cites W1964717752 @default.
- W1970282892 cites W1974091610 @default.
- W1970282892 cites W1983322673 @default.
- W1970282892 cites W1985165153 @default.
- W1970282892 cites W1998735143 @default.
- W1970282892 cites W2001701624 @default.
- W1970282892 cites W2002393139 @default.
- W1970282892 cites W2024223532 @default.
- W1970282892 cites W2025722734 @default.
- W1970282892 cites W2043838926 @default.
- W1970282892 cites W2052851334 @default.
- W1970282892 cites W2053440894 @default.
- W1970282892 cites W2056077453 @default.
- W1970282892 cites W2063762009 @default.
- W1970282892 cites W2064559651 @default.
- W1970282892 cites W2069771231 @default.
- W1970282892 cites W2071463327 @default.
- W1970282892 cites W2073766903 @default.
- W1970282892 cites W2074420943 @default.
- W1970282892 cites W2076187086 @default.
- W1970282892 cites W2078573317 @default.
- W1970282892 cites W2084954701 @default.
- W1970282892 cites W2089226835 @default.
- W1970282892 cites W2091862394 @default.
- W1970282892 cites W2097667423 @default.
- W1970282892 cites W2107833602 @default.
- W1970282892 cites W2109630790 @default.
- W1970282892 cites W2111125148 @default.
- W1970282892 cites W2111299301 @default.
- W1970282892 cites W2127538166 @default.
- W1970282892 cites W2127993259 @default.
- W1970282892 cites W2137702309 @default.
- W1970282892 cites W2138422114 @default.
- W1970282892 cites W2140100159 @default.
- W1970282892 cites W2148866177 @default.
- W1970282892 cites W2154909240 @default.
- W1970282892 cites W2155403267 @default.
- W1970282892 cites W2158234688 @default.
- W1970282892 cites W2158270251 @default.
- W1970282892 cites W2159850373 @default.
- W1970282892 cites W2163500752 @default.
- W1970282892 cites W2163912020 @default.
- W1970282892 cites W2164230754 @default.
- W1970282892 cites W2166771547 @default.
- W1970282892 doi "https://doi.org/10.1016/j.micpath.2010.01.001" @default.
- W1970282892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20060886" @default.
- W1970282892 hasPublicationYear "2010" @default.
- W1970282892 type Work @default.
- W1970282892 sameAs 1970282892 @default.
- W1970282892 citedByCount "19" @default.
- W1970282892 countsByYear W19702828922012 @default.
- W1970282892 countsByYear W19702828922013 @default.
- W1970282892 countsByYear W19702828922015 @default.
- W1970282892 countsByYear W19702828922016 @default.
- W1970282892 countsByYear W19702828922017 @default.
- W1970282892 countsByYear W19702828922019 @default.
- W1970282892 countsByYear W19702828922020 @default.
- W1970282892 countsByYear W19702828922021 @default.
- W1970282892 countsByYear W19702828922022 @default.
- W1970282892 countsByYear W19702828922023 @default.
- W1970282892 crossrefType "journal-article" @default.
- W1970282892 hasAuthorship W1970282892A5006615953 @default.
- W1970282892 hasAuthorship W1970282892A5007480024 @default.
- W1970282892 hasAuthorship W1970282892A5027754047 @default.
- W1970282892 hasConcept C104317684 @default.
- W1970282892 hasConcept C144647389 @default.
- W1970282892 hasConcept C146587185 @default.
- W1970282892 hasConcept C159654299 @default.
- W1970282892 hasConcept C181199279 @default.
- W1970282892 hasConcept C185592680 @default.
- W1970282892 hasConcept C203014093 @default.
- W1970282892 hasConcept C2776217839 @default.
- W1970282892 hasConcept C2776357993 @default.
- W1970282892 hasConcept C2777723881 @default.
- W1970282892 hasConcept C2778692840 @default.
- W1970282892 hasConcept C2780183776 @default.
- W1970282892 hasConcept C34343649 @default.
- W1970282892 hasConcept C40767141 @default.
- W1970282892 hasConcept C41625074 @default.
- W1970282892 hasConcept C523546767 @default.
- W1970282892 hasConcept C542903549 @default.
- W1970282892 hasConcept C54355233 @default.
- W1970282892 hasConcept C547475151 @default.