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- W1970288510 abstract "P1155 Aims: CXCR3 binding chemokines play a key role in recruitment of inflammatory cells into an organ transplant, this study addresses the question of whether urinary excretion of these chemokines correlates with acute rejection in a baboon kidney transplantation model. Methods: Seven outbred baboons underwent renal allotransplantation from MHC-mismatched donors. The treatment of baboons consisted of anti-CD4 monoclonal antibody (mAb), anti-CD8 mAb, rapamycin, and mycophenolate mofetil (MMF). Urinary levels of interferon-γ inducible protein-10 (IP-10) and monokine induced by interferon-γ (Mig) were determined by ELISA. Renal biopsies were examined by immunohistochemical staining for CXCR3 and Mig. Results: Urinary levels of IP-10 and Mig increased significantly in all of the 5 baboons at the time of acute rejection of renal transplant. The IP-10 and Mig levels did not rise in 2 non-rejecting baboons. In 2 baboons, urinary levels of IP-10 and Mig rose prior to the elevation of the serum Cr. In renal biopsies expression of Mig was detected in glomeruli, tubules and infiltrating cells, and the expression was significantly elevated in biopsies with acute rejection (P<0.01). CXCR3 was constitutively expressed in tubular cells in biopsies derived from both normal grafts and grafts with acute rejection. While the infiltrating cells were increased in the biopsies with acute rejection, the expression of CXCR3 was also significantly higher (P<0.01) in these infiltrating cells compared to those in the normal controls. Conclusions: This study shows an important correlation between urinary excretion of IP-10 and Mig and acute rejection in baboon kidney transplantation." @default.
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- W1970288510 date "2004-07-01" @default.
- W1970288510 modified "2023-09-26" @default.
- W1970288510 title "SURVEILLANCE OF ACUTE REJECTION IN BABOON RENAL TRANSPLANTATION BY ELEVATION OF IP-10 AND MIG IN URINE" @default.
- W1970288510 doi "https://doi.org/10.1097/00007890-200407271-01651" @default.
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