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- W1970295055 abstract "Abstract The neurochemical effects of a coma-producing material from mammalian brain have been studied in rats and mice. During coma, there was a decrease in brain glucose, glycogen, ATP and creatine phosphate, and an increase in brain inorganic phosphate and lactate. After recovery of the righting reflex, brain glycogen levels remained depressed but there was a compensatory rise in brain glucose. Brain ammonia and liver ATP and glycogen levels were unaltered during the experimental period. The uptake of 14 C-glucose was severely retarded both during coma and after the recovery of the righting reflex, whereas the uptake of acridine orange was unaffected. As a working hypothesis, it is suggested that the coma-producing material caused these neurochemical effects by blocking the uptake of glucose into the brain." @default.
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- W1970295055 date "1970-09-01" @default.
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- W1970295055 title "Neurochemical effects of a coma-producing material from mammalian brain" @default.
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- W1970295055 doi "https://doi.org/10.1016/0028-3908(70)90022-5" @default.
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