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• W1970296857 startingPage "1523" @default.
• W1970296857 abstract "Macromolecularly imprinted polymers have been developed to mimic the non-covalent interactions driving molecular recognition in nature. The creation of an engineered antibody mimic would allow for the development of customizable films for biomolecular sensing. To demonstrate this principle, a cross-linked alginate film has been imprinted with bovine serum albumin (BSA) using aqueous biocompatible gelation methods. The imprinting efficiency of the synthesized films imprinted with BSA was determined and compared to the non-specific uptake of complementary proteins which were not imprinted in the alginate matrix. It was found that the recognition of the BSA using an alginate film was 6.4 mg/g polymer, which compares favorably to previously reported macromolecularly imprinted networks. The absorption of non-imprinted cationic proteins by the alginate matrix demonstrates that overcoming non-specific binding needs to be a focus of future work in order to successfully employ these materials towards biomolecular sensing within a physiological environment." @default.
• W1970296857 created "2016-06-24" @default.
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• W1970296857 date "2011-01-01" @default.
• W1970296857 modified "2023-10-14" @default.
• W1970296857 title "Alginate Films as Macromolecular Imprinted Matrices" @default.
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• W1970296857 doi "https://doi.org/10.1163/092050610x514115" @default.
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• W1970296857 hasPublicationYear "2011" @default.
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