FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970302682> ?p ?o ?g. }

• W1970302682 endingPage "132" @default.
• W1970302682 startingPage "127" @default.
• W1970302682 abstract "Maritime pine bark extract is monographed in the United States Pharmacopeia (USP) as a dietary supplement. As knowledge about active principles - protein interactions contribute to insights into pharmacokinetic and pharmacodynamic properties we elucidated the plasma protein binding of various constituents and metabolites of this extract. We chose high performance affinity chromatography for fast characterization of the analytes' binding extent to human serum albumin. For selected maritime pine bark compounds that were previously detected in human plasma samples we additionally employed ultrafiltration. The flavonoids catechin and taxifolin revealed highest plasma protein binding of close to 100%, followed by procyanidin B1 and the cinnamic acid derivates ferulic acid (73.5 ± 0.12%), caffeic acid (66.0 ± 0.23%) and p-cumaric acid (65.4 ± 4.84%). Lower protein binding was observed for the benzoic acid derivates vanillic acid (56.3 ± 1.16%), p-hydroxy benzoic acid (35.3 ± 10.9%), gallic acid (31.6 ± 0.56%) and protocatechuic acid (20.7 ± 0.09%). Lowest protein binding was measured for the maritime pine bark metabolites δ-(3,4-dihydroxy-phenyl)-γ-valerolactone (34.9 ± 1.28%) and δ-(3-methoxy-4-hydroxy-phenyl)-γ-valerolactone (26.4 ± 0.03%). For all but one compound the results of both methods revealed excellent correlation. Thus, we provide new data as a basis for a more comprehensive understanding of the bioactivity of a complex plant extract." @default.
• W1970302682 created "2016-06-24" @default.
• W1970302682 creator A5040653638 @default.
• W1970302682 creator A5048193060 @default.
• W1970302682 date "2011-01-01" @default.
• W1970302682 modified "2023-10-14" @default.
• W1970302682 title "Plasma protein binding of polyphenols from maritime pine bark extract (USP)" @default.
• W1970302682 cites W1528363227 @default.
• W1970302682 cites W1646897293 @default.
• W1970302682 cites W1908943466 @default.
• W1970302682 cites W1928608880 @default.
• W1970302682 cites W1977698530 @default.
• W1970302682 cites W1983543493 @default.
• W1970302682 cites W1987380529 @default.
• W1970302682 cites W1996495207 @default.
• W1970302682 cites W1999009220 @default.
• W1970302682 cites W2007125963 @default.
• W1970302682 cites W2010160275 @default.
• W1970302682 cites W2010243276 @default.
• W1970302682 cites W2012296679 @default.
• W1970302682 cites W2014332957 @default.
• W1970302682 cites W2018607875 @default.
• W1970302682 cites W2021967628 @default.
• W1970302682 cites W2034189042 @default.
• W1970302682 cites W2049684731 @default.
• W1970302682 cites W2051963341 @default.
• W1970302682 cites W2061097462 @default.
• W1970302682 cites W2067044904 @default.
• W1970302682 cites W2067268305 @default.
• W1970302682 cites W2068359234 @default.
• W1970302682 cites W2082068278 @default.
• W1970302682 cites W2082878908 @default.
• W1970302682 cites W2086389237 @default.
• W1970302682 cites W2121713592 @default.
• W1970302682 cites W2126204287 @default.
• W1970302682 cites W2138187438 @default.
• W1970302682 cites W2139852945 @default.
• W1970302682 cites W2141695969 @default.
• W1970302682 cites W2153556181 @default.
• W1970302682 cites W2156046395 @default.
• W1970302682 cites W2160357565 @default.
• W1970302682 cites W2168229944 @default.
• W1970302682 cites W2168276530 @default.
• W1970302682 cites W530199 @default.
• W1970302682 doi "https://doi.org/10.1016/j.jpba.2010.07.038" @default.
• W1970302682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20732774" @default.
• W1970302682 hasPublicationYear "2011" @default.
• W1970302682 type Work @default.
• W1970302682 sameAs 1970302682 @default.
• W1970302682 citedByCount "38" @default.
• W1970302682 countsByYear W19703026822012 @default.
• W1970302682 countsByYear W19703026822013 @default.
• W1970302682 countsByYear W19703026822014 @default.
• W1970302682 countsByYear W19703026822015 @default.
• W1970302682 countsByYear W19703026822017 @default.
• W1970302682 countsByYear W19703026822018 @default.
• W1970302682 countsByYear W19703026822019 @default.
• W1970302682 countsByYear W19703026822020 @default.
• W1970302682 countsByYear W19703026822021 @default.
• W1970302682 countsByYear W19703026822022 @default.
• W1970302682 countsByYear W19703026822023 @default.
• W1970302682 crossrefType "journal-article" @default.
• W1970302682 hasAuthorship W1970302682A5040653638 @default.
• W1970302682 hasAuthorship W1970302682A5048193060 @default.
• W1970302682 hasConcept C121332964 @default.
• W1970302682 hasConcept C133446333 @default.
• W1970302682 hasConcept C185592680 @default.
• W1970302682 hasConcept C24890656 @default.
• W1970302682 hasConcept C2776549161 @default.
• W1970302682 hasConcept C2778004101 @default.
• W1970302682 hasConcept C2778224086 @default.
• W1970302682 hasConcept C2778362808 @default.
• W1970302682 hasConcept C2778778762 @default.
• W1970302682 hasConcept C2778831176 @default.
• W1970302682 hasConcept C2778844314 @default.
• W1970302682 hasConcept C2779431889 @default.
• W1970302682 hasConcept C2780213334 @default.
• W1970302682 hasConcept C2781203734 @default.
• W1970302682 hasConcept C43617362 @default.
• W1970302682 hasConcept C55493867 @default.
• W1970302682 hasConcept C70899900 @default.
• W1970302682 hasConceptScore W1970302682C121332964 @default.
• W1970302682 hasConceptScore W1970302682C133446333 @default.
• W1970302682 hasConceptScore W1970302682C185592680 @default.
• W1970302682 hasConceptScore W1970302682C24890656 @default.
• W1970302682 hasConceptScore W1970302682C2776549161 @default.
• W1970302682 hasConceptScore W1970302682C2778004101 @default.
• W1970302682 hasConceptScore W1970302682C2778224086 @default.
• W1970302682 hasConceptScore W1970302682C2778362808 @default.
• W1970302682 hasConceptScore W1970302682C2778778762 @default.
• W1970302682 hasConceptScore W1970302682C2778831176 @default.
• W1970302682 hasConceptScore W1970302682C2778844314 @default.
• W1970302682 hasConceptScore W1970302682C2779431889 @default.
• W1970302682 hasConceptScore W1970302682C2780213334 @default.
• W1970302682 hasConceptScore W1970302682C2781203734 @default.
• W1970302682 hasConceptScore W1970302682C43617362 @default.
• W1970302682 hasConceptScore W1970302682C55493867 @default.
• W1970302682 hasConceptScore W1970302682C70899900 @default.

• next