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- W1970332014 abstract "Leu-enkephalin (100 ug/kg, i.p.) administered to mice 5 min before training in a one way active avoidance task significantly reduced the number of avoidance observed in the peptide treated animals. This impairing action of Leu-enkephalin was partially attenuated by methylnaloxonium (naloxonium), a quarternary form of naloxone with a limited ability to penetrate the blood brain barrier. Passive immunization (i.v.) of mice with a Leu-enkephalin antiserum 4 hrs before training produced an effect on avoidance conditioning that was the opposite to that observed with Leu-enkephalin alone. That is, passive immunization increased the number of avoidances observed in the treated mice. The results suggest that Leu-enkephalin actions on avoidance conditioning are mediated by a peripheral opioid mechanism, that leu-enkephalin may have a primary site of action outside the blood brain barrier, and that peripheral Leu-enkephalin systems may normally operate to influence conditioned avoidance behavior." @default.
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- W1970332014 date "1985-12-01" @default.
- W1970332014 modified "2023-10-17" @default.
- W1970332014 title "Leu-enkephalin actions on avoidance conditioning are mediated by a peripheral opioid mechanism" @default.
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- W1970332014 doi "https://doi.org/10.1016/0024-3205(85)90101-8" @default.
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