FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970334666> ?p ?o ?g. }

• W1970334666 endingPage "2643" @default.
• W1970334666 startingPage "2635" @default.
• W1970334666 abstract "Recent NMR-based, chemical shift mapping experiments with the minimal DNA-binding domain of XPA (XPA-MBD: M98–F219) suggest that a basic cleft located in the loop-rich subdomain plays a role in DNA-binding. Here, XPA–DNA interactions are further characterized by NMR spectroscopy from the vantage point of the DNA using a single-stranded DNA nonamer, dCCAATAACC (d9). Up to 2.5 molar equivalents of XPA-MBD was titrated into a solution of d9. A subset of 31P resonances of d9 were observed to broaden and/or shift providing direct evidence that XPA-MBD binds d9 by a mechanism that perturbs the phosphodiester backbone of d9. The interior five residues of d9 broadened and/or shifted before 31P resonances of phosphate groups at the termini, suggesting that when d9 is bound to XPA-MBD the internal residues assume a correlation time that is characteristic of the molecular weight of the complex while the residues at the termini undergo a fraying motion away from the surface of the protein on a timescale such that the line widths are more characteristic of the molecular weight of ssDNA. A molecular model of the XPA-MBD complex with d9 was calculated based on the 15N (XPA-MBD) and 31P (d9) chemical shift mapping studies and on the assumption that electrostatic interactions drive the complex formation. The model shows that a nine residue DNA oligomer fully covers the DNA-binding surface of XPA and that there may be an energetic advantage to binding DNA in the 3′→5′ direction rather than in the 5′→3′ direction (relative to XPA-MBD α-helix-3)." @default.
• W1970334666 created "2016-06-24" @default.
• W1970334666 creator A5015649188 @default.
• W1970334666 creator A5025128691 @default.
• W1970334666 creator A5033465444 @default.
• W1970334666 creator A5040890081 @default.
• W1970334666 creator A5052450940 @default.
• W1970334666 creator A5069241881 @default.
• W1970334666 date "2001-06-15" @default.
• W1970334666 modified "2023-10-16" @default.
• W1970334666 title "DNA-XPA interactions: a 31P NMR and molecular modeling study of dCCAATAACC association with the minimal DNA-binding domain (M98-F219) of the nucleotide excision repair protein XPA" @default.
• W1970334666 cites W12794080 @default.
• W1970334666 cites W1553750373 @default.
• W1970334666 cites W1798376596 @default.
• W1970334666 cites W1963719191 @default.
• W1970334666 cites W1969769040 @default.
• W1970334666 cites W1985056911 @default.
• W1970334666 cites W1992431849 @default.
• W1970334666 cites W1993559085 @default.
• W1970334666 cites W1993844842 @default.
• W1970334666 cites W1994875540 @default.
• W1970334666 cites W1994982452 @default.
• W1970334666 cites W1995021789 @default.
• W1970334666 cites W1996566112 @default.
• W1970334666 cites W2000936373 @default.
• W1970334666 cites W2000983378 @default.
• W1970334666 cites W2005943555 @default.
• W1970334666 cites W2006641720 @default.
• W1970334666 cites W2010055022 @default.
• W1970334666 cites W2016226166 @default.
• W1970334666 cites W2018982396 @default.
• W1970334666 cites W2020651808 @default.
• W1970334666 cites W2020761966 @default.
• W1970334666 cites W2021485188 @default.
• W1970334666 cites W2024322354 @default.
• W1970334666 cites W2030433731 @default.
• W1970334666 cites W2044000184 @default.
• W1970334666 cites W2048725347 @default.
• W1970334666 cites W2052888487 @default.
• W1970334666 cites W2057692066 @default.
• W1970334666 cites W2064235474 @default.
• W1970334666 cites W2069602336 @default.
• W1970334666 cites W2070007155 @default.
• W1970334666 cites W2070821144 @default.
• W1970334666 cites W2073134966 @default.
• W1970334666 cites W2078882775 @default.
• W1970334666 cites W2081049803 @default.
• W1970334666 cites W2085143427 @default.
• W1970334666 cites W2088940333 @default.
• W1970334666 cites W2091566576 @default.
• W1970334666 cites W2098632836 @default.
• W1970334666 cites W2115875779 @default.
• W1970334666 cites W2116298638 @default.
• W1970334666 cites W2120988887 @default.
• W1970334666 cites W2127547755 @default.
• W1970334666 cites W2136199465 @default.
• W1970334666 cites W2142355539 @default.
• W1970334666 cites W2144792857 @default.
• W1970334666 cites W2154056201 @default.
• W1970334666 cites W2155524113 @default.
• W1970334666 cites W2157811245 @default.
• W1970334666 cites W2158680852 @default.
• W1970334666 cites W2169947235 @default.
• W1970334666 cites W2172916891 @default.
• W1970334666 cites W2417461150 @default.
• W1970334666 doi "https://doi.org/10.1093/nar/29.12.2635" @default.
• W1970334666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/55733" @default.
• W1970334666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11410673" @default.
• W1970334666 hasPublicationYear "2001" @default.
• W1970334666 type Work @default.
• W1970334666 sameAs 1970334666 @default.
• W1970334666 citedByCount "27" @default.
• W1970334666 countsByYear W19703346662013 @default.
• W1970334666 countsByYear W19703346662014 @default.
• W1970334666 countsByYear W19703346662016 @default.
• W1970334666 countsByYear W19703346662017 @default.
• W1970334666 countsByYear W19703346662018 @default.
• W1970334666 countsByYear W19703346662022 @default.
• W1970334666 crossrefType "journal-article" @default.
• W1970334666 hasAuthorship W1970334666A5015649188 @default.
• W1970334666 hasAuthorship W1970334666A5025128691 @default.
• W1970334666 hasAuthorship W1970334666A5033465444 @default.
• W1970334666 hasAuthorship W1970334666A5040890081 @default.
• W1970334666 hasAuthorship W1970334666A5052450940 @default.
• W1970334666 hasAuthorship W1970334666A5069241881 @default.
• W1970334666 hasBestOaLocation W19703346661 @default.
• W1970334666 hasConcept C104317684 @default.
• W1970334666 hasConcept C104451858 @default.
• W1970334666 hasConcept C12554922 @default.
• W1970334666 hasConcept C134935766 @default.
• W1970334666 hasConcept C38441620 @default.
• W1970334666 hasConcept C512185932 @default.
• W1970334666 hasConcept C552990157 @default.
• W1970334666 hasConcept C55493867 @default.
• W1970334666 hasConcept C67705224 @default.
• W1970334666 hasConcept C86803240 @default.
• W1970334666 hasConceptScore W1970334666C104317684 @default.
• W1970334666 hasConceptScore W1970334666C104451858 @default.

• next