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- W1970343120 abstract "Abstract Significant decreases in zoxazolamine paralysis and hexobarbital sleeping times were observed in mice following pretreatment with DDT, phenobarbital or benzpyrene. In parallel experiments, highly significant elevations were noted in the cytochrome P450 level and the 430 and 455 nm peaks of the ethyl isocyanide spectra of cytochrome P450. These increases greatly exceeded those increases observed for liver wet weight and microsomal protein. No shifts in the ethyl isocyanide pH equilibrium point were noted when mice were pretreated with DDT, phenobarbital or benzpyrene. In contrast to experiments reported on other mice, DDT appears to be a non-sclective inducer in the strain examined." @default.
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- W1970343120 date "1971-09-01" @default.
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- W1970343120 title "Inductive effects of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane(DDT), phenobarbital, and benzpyrene on microsomal cytochrome P450, ethyl isocyanide spectra, and metabolism in vivo of zoxazolamine and hexobarbital in the mouse" @default.
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- W1970343120 doi "https://doi.org/10.1016/0006-2952(71)90239-5" @default.
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