Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970343457> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1970343457 endingPage "94" @default.
- W1970343457 startingPage "93" @default.
- W1970343457 abstract "Type 2 diabetes increases the risk of cardiovascular disease (CVD) and reducing this disease burden through glycaemic control has long been the principal objective of treating the disease. No treatment has yet succeeded in reaching this objective. There are concerns that sulfonylurea (SU) medications may increase, rather than decrease this risk.SUs have been central to the management of type 2 diabetes for many decades. Every month, more than 600 000 prescriptions for SUs are dispensed in England and current National Institute for Health and Care Excellence (NICE) guidelines recommend them for second-line use after metformin. The American College of Endocrinologists downgraded this role for SUs in 2009 and the European Association for the Study of Diabetes (EASD) did likewise in 2012.There are three major concerns regarding SUs. Firstly their widely acknowledged and indisputable tendency to cause hypoglycaemia.Second is the belief that they accelerate beta pancreatic cell failure. This was demonstrated by their marked lack of durability in maintaining glycaemic control in the UK Prospective Diabetes Study (UKPDS) and ADOPT (A Diabetes Outcome Progression Trial) study. This was highlighted by Ralph de Fronzo in his 2008 American Diabetes Association’s Banting lecture, in which he declared that: ‘Sulfonylureas are not recommended because, after an initial improvement in glycaemic control, they are associated with a progressive rise in HbA1c and progressive loss of beta cell function’. 1The third and most worrying concern regarding SUs relates to questions regarding their cardiovascular safety. These questions have remained unanswered for more than 40 years.The University Group …" @default.
- W1970343457 created "2016-06-24" @default.
- W1970343457 creator A5035502626 @default.
- W1970343457 date "2015-01-26" @default.
- W1970343457 modified "2023-09-25" @default.
- W1970343457 title "Time to be cautious about prescribing sulfonylureas?" @default.
- W1970343457 cites W2037316673 @default.
- W1970343457 cites W2043518164 @default.
- W1970343457 cites W2043807347 @default.
- W1970343457 cites W2057397568 @default.
- W1970343457 cites W2078482750 @default.
- W1970343457 cites W2095784604 @default.
- W1970343457 cites W2100862440 @default.
- W1970343457 cites W2107166617 @default.
- W1970343457 cites W2109728760 @default.
- W1970343457 cites W2114349038 @default.
- W1970343457 cites W2131830909 @default.
- W1970343457 cites W2137097374 @default.
- W1970343457 cites W2171646682 @default.
- W1970343457 cites W2172193326 @default.
- W1970343457 cites W2302447233 @default.
- W1970343457 cites W2337454357 @default.
- W1970343457 doi "https://doi.org/10.3399/bjgp15x683617" @default.
- W1970343457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4325462" @default.
- W1970343457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25624301" @default.
- W1970343457 hasPublicationYear "2015" @default.
- W1970343457 type Work @default.
- W1970343457 sameAs 1970343457 @default.
- W1970343457 citedByCount "0" @default.
- W1970343457 crossrefType "journal-article" @default.
- W1970343457 hasAuthorship W1970343457A5035502626 @default.
- W1970343457 hasBestOaLocation W19703434571 @default.
- W1970343457 hasConcept C17744445 @default.
- W1970343457 hasConcept C177713679 @default.
- W1970343457 hasConcept C199539241 @default.
- W1970343457 hasConcept C2522767166 @default.
- W1970343457 hasConcept C2779473830 @default.
- W1970343457 hasConcept C41008148 @default.
- W1970343457 hasConcept C71924100 @default.
- W1970343457 hasConceptScore W1970343457C17744445 @default.
- W1970343457 hasConceptScore W1970343457C177713679 @default.
- W1970343457 hasConceptScore W1970343457C199539241 @default.
- W1970343457 hasConceptScore W1970343457C2522767166 @default.
- W1970343457 hasConceptScore W1970343457C2779473830 @default.
- W1970343457 hasConceptScore W1970343457C41008148 @default.
- W1970343457 hasConceptScore W1970343457C71924100 @default.
- W1970343457 hasIssue "631" @default.
- W1970343457 hasLocation W19703434571 @default.
- W1970343457 hasLocation W19703434572 @default.
- W1970343457 hasLocation W19703434573 @default.
- W1970343457 hasLocation W19703434574 @default.
- W1970343457 hasOpenAccess W1970343457 @default.
- W1970343457 hasPrimaryLocation W19703434571 @default.
- W1970343457 hasRelatedWork W1798870981 @default.
- W1970343457 hasRelatedWork W1970371692 @default.
- W1970343457 hasRelatedWork W2021863254 @default.
- W1970343457 hasRelatedWork W2086802883 @default.
- W1970343457 hasRelatedWork W2170981806 @default.
- W1970343457 hasRelatedWork W2289435061 @default.
- W1970343457 hasRelatedWork W2737571454 @default.
- W1970343457 hasRelatedWork W3190644262 @default.
- W1970343457 hasRelatedWork W4252371801 @default.
- W1970343457 hasRelatedWork W4281915604 @default.
- W1970343457 hasVolume "65" @default.
- W1970343457 isParatext "false" @default.
- W1970343457 isRetracted "false" @default.
- W1970343457 magId "1970343457" @default.
- W1970343457 workType "article" @default.