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• W1970357818 abstract "E NDOMYOCARDIAL DISEASE belongs to the group of cardiomyopathies defined as heart muscle disease of unknown cause. Endomyocardial disease belongs to the restrictive type of cardiomyopathies, the other two are dilated and hypertrophic types.’ Evidence continues to accumulate that a close connection exists between eosinophilia and endomyocardial disease. There is also now overwhelming evidence that endomyocardial disease represents a single disease entity irrespective of the geographical distribution as to where it occurs.’ Initially, endomyocardial fibrosis, detailed clinically in 194& and pathologically in 194g4 was considered to be a cardiac disease confined to Africa. It was soon learned that other tropical areas such as Brazil, Venezuela, and Ceylon were also affected,5 roughly following the “belt” of Burkitt’s lymphoma. An entity of endomyocardial disease, believed to be separate and different was described in 193@ and bore the eponym of Liiffler’s endocarditis parietalis fibroplastica and is now frequently referred to as LSffler’s endomyocardial disease, though the first case was described by Reinbach at the end of the 19th century? This type of cardiac disease was thought to predominate in the temperate zones and occurred in association with an eosinophilia. The observations that eosinophilia and endomyocardial disease occur together is not new and a wealth of literature beginning from the end of the 19th century testifies to that association.2v8*9 Acceptance of the evidence that both Liiffler’s endomyocardial disease on the one hand and endomyocardial fibrosis on the other are in fact one disease entity has been slow. In 1956 Gerbaux et al” had noted endomyocardial disease in association with eosinophilia in the tropics. This was referred to as Liiffler’s endocarditis. In 1967 Ive et al” noted the geographical incidence of endomyocardial fibrosis in Nigeria with filariasis (and consequent eosinophilia) in Nigeria but the similarities and causal relationship of eosinophilia to endomyocardial disease was not emphasized. The suggestion of a link was subsequently made on two cases of “eosinophilic leukemia” and the spectrum beginning with tropical eosinophilia to LSffler’s disease and finally to endomyocardial fibrosis was suggested.‘* Almost simultaneously another case was reported from Nigeria.13 To clarify the Unitarian theory, descriptions of the entities, both clinically and pathologically, will be separately detailed, emphasizing the features of one and pointing out the differences from the other." @default.
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• W1970357818 date "1985-01-01" @default.
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• W1970357818 title "Relation between eosinophilia and endomyocardial disease" @default.
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• W1970357818 doi "https://doi.org/10.1016/0033-0620(85)90008-8" @default.
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