Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970362604> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1970362604 endingPage "215" @default.
- W1970362604 startingPage "210" @default.
- W1970362604 abstract "Incorporation of fluorine into antibiotics can moderate their biological activity, lipophilicity and metabolic stability. The introduction of fluorine into an antimicrobial lipopeptide produced by Bacillus sp. CS93 via precursor-directed biosynthesis is described. The lipopeptide surfactin is synthesised non-ribosomally by various Bacillus species and is known for its biological activity. Administering 4,4,4-trifluoro-dl-valine to cultures of Bacillus sp. CS93 results in the formation of trifluorosurfactin in quantities sufficient for detection by LC–MS/MS. 19F NMR analysis of the culture supernatant revealed that the bulk of the fluorinated amino acid was transformed and thus was unavailable for incorporation into surfactin. Detection of ammonia, and MS analysis indicated that the transformation proceeds with deamination and reduction of the keto acid, yielding 4,4,4-trifluoro-2-hydroxy-3-methylbutanoic acid." @default.
- W1970362604 created "2016-06-24" @default.
- W1970362604 creator A5002656380 @default.
- W1970362604 creator A5025717652 @default.
- W1970362604 creator A5062418168 @default.
- W1970362604 creator A5076798079 @default.
- W1970362604 date "2012-11-01" @default.
- W1970362604 modified "2023-09-26" @default.
- W1970362604 title "Production of the novel lipopeptide antibiotic trifluorosurfactin via precursor-directed biosynthesis" @default.
- W1970362604 cites W1515668124 @default.
- W1970362604 cites W1902681617 @default.
- W1970362604 cites W1971788278 @default.
- W1970362604 cites W1989784369 @default.
- W1970362604 cites W1990522875 @default.
- W1970362604 cites W2038394216 @default.
- W1970362604 cites W2048111541 @default.
- W1970362604 cites W2049083467 @default.
- W1970362604 cites W2050331584 @default.
- W1970362604 cites W2057081045 @default.
- W1970362604 cites W2068441590 @default.
- W1970362604 cites W2101881683 @default.
- W1970362604 cites W2116087305 @default.
- W1970362604 cites W2162591317 @default.
- W1970362604 cites W2169233127 @default.
- W1970362604 cites W3487810 @default.
- W1970362604 doi "https://doi.org/10.1016/j.jfluchem.2012.06.033" @default.
- W1970362604 hasPublicationYear "2012" @default.
- W1970362604 type Work @default.
- W1970362604 sameAs 1970362604 @default.
- W1970362604 citedByCount "9" @default.
- W1970362604 countsByYear W19703626042014 @default.
- W1970362604 countsByYear W19703626042015 @default.
- W1970362604 countsByYear W19703626042021 @default.
- W1970362604 countsByYear W19703626042023 @default.
- W1970362604 crossrefType "journal-article" @default.
- W1970362604 hasAuthorship W1970362604A5002656380 @default.
- W1970362604 hasAuthorship W1970362604A5025717652 @default.
- W1970362604 hasAuthorship W1970362604A5062418168 @default.
- W1970362604 hasAuthorship W1970362604A5076798079 @default.
- W1970362604 hasBestOaLocation W19703626042 @default.
- W1970362604 hasConcept C178790620 @default.
- W1970362604 hasConcept C181199279 @default.
- W1970362604 hasConcept C185592680 @default.
- W1970362604 hasConcept C201399114 @default.
- W1970362604 hasConcept C21951064 @default.
- W1970362604 hasConcept C2776102837 @default.
- W1970362604 hasConcept C2777272437 @default.
- W1970362604 hasConcept C2777425210 @default.
- W1970362604 hasConcept C2777573094 @default.
- W1970362604 hasConcept C515207424 @default.
- W1970362604 hasConcept C523546767 @default.
- W1970362604 hasConcept C54355233 @default.
- W1970362604 hasConcept C553450214 @default.
- W1970362604 hasConcept C55493867 @default.
- W1970362604 hasConcept C71240020 @default.
- W1970362604 hasConcept C86803240 @default.
- W1970362604 hasConceptScore W1970362604C178790620 @default.
- W1970362604 hasConceptScore W1970362604C181199279 @default.
- W1970362604 hasConceptScore W1970362604C185592680 @default.
- W1970362604 hasConceptScore W1970362604C201399114 @default.
- W1970362604 hasConceptScore W1970362604C21951064 @default.
- W1970362604 hasConceptScore W1970362604C2776102837 @default.
- W1970362604 hasConceptScore W1970362604C2777272437 @default.
- W1970362604 hasConceptScore W1970362604C2777425210 @default.
- W1970362604 hasConceptScore W1970362604C2777573094 @default.
- W1970362604 hasConceptScore W1970362604C515207424 @default.
- W1970362604 hasConceptScore W1970362604C523546767 @default.
- W1970362604 hasConceptScore W1970362604C54355233 @default.
- W1970362604 hasConceptScore W1970362604C553450214 @default.
- W1970362604 hasConceptScore W1970362604C55493867 @default.
- W1970362604 hasConceptScore W1970362604C71240020 @default.
- W1970362604 hasConceptScore W1970362604C86803240 @default.
- W1970362604 hasLocation W19703626041 @default.
- W1970362604 hasLocation W19703626042 @default.
- W1970362604 hasOpenAccess W1970362604 @default.
- W1970362604 hasPrimaryLocation W19703626041 @default.
- W1970362604 hasRelatedWork W1970362604 @default.
- W1970362604 hasRelatedWork W1975627845 @default.
- W1970362604 hasRelatedWork W2019203966 @default.
- W1970362604 hasRelatedWork W2029769934 @default.
- W1970362604 hasRelatedWork W2301188081 @default.
- W1970362604 hasRelatedWork W2331932260 @default.
- W1970362604 hasRelatedWork W2387150264 @default.
- W1970362604 hasRelatedWork W2408613248 @default.
- W1970362604 hasRelatedWork W3202374504 @default.
- W1970362604 hasRelatedWork W49067265 @default.
- W1970362604 hasVolume "143" @default.
- W1970362604 isParatext "false" @default.
- W1970362604 isRetracted "false" @default.
- W1970362604 magId "1970362604" @default.
- W1970362604 workType "article" @default.