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- W1970367941 abstract "The multixenobiotic resistance (MXR) mechanism, mediated by activity of the transmembrane P-glycoprotein, represents a basic biological defence system in aquatic organisms. Here we investigate the MXR transport activity in an aquatic vertebrate, the common carp (Cyprinus carpio). We measured the accumulation rate of a model MXR substrate, the fluorescent dye rhodamine B (RB), in gills, lateral muscles, liver and bile. Results obtained using this method showed a significant increase of RB accumulation in tissues of fish exposed for I h to 3 microM RB in the presence of the model MXR inhibitors cyclosporin A (CA, 5 microM) or verapamil (VER, 10 microM), when compared with specimens exposed without inhibitors. The highest increase in RB accumulation detected in the liver (VER 54%, CA 170%) indicates that among the tissues analysed within this study, liver is the most prominent candidate organ for the functional detection of MXR activity in C. carpio." @default.
- W1970367941 created "2016-06-24" @default.
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- W1970367941 date "2002-09-01" @default.
- W1970367941 modified "2023-09-27" @default.
- W1970367941 title "Measurement of the activity of multixenobiotic resistance mechanism in the common carp Cyprinus carpio" @default.
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- W1970367941 doi "https://doi.org/10.1016/s0141-1136(02)00155-1" @default.
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