FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970369110> ?p ?o ?g. }

• W1970369110 endingPage "261" @default.
• W1970369110 startingPage "253" @default.
• W1970369110 abstract "Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) are functionally related hematopoietins with overlapping but distinct hematopoietic effects. GM-CSF supports more myeloid progenitor cells, whereas IL-3 promotes more erythroid, megakaryocytic and multipotential progenitor cells. Their complementary in vivo biological effects and cross competition for receptor binding prompted the development of PIXY321, a synthetic hybrid protein of GM-CSF and IL-3. PIXY321 binds to cell lines expressing specific receptors for either ligand, and it exhibits enhanced biological activity in human hematopoietic progenitor cell assays. In preclinical studies, PIXY321 has been shown to accelerate both neutrophil and platelet recovery in rhesus monkeys subjected to sublethal irradiation. Based on these preclinical observations, clinical trials have been initiated examining the therapeutic potential of this agent in ameliorating treatment- or disease-related hematopoietic suppression. The early results indicate that PIXY321 can stimulate multilineage hematopoiesis in vivo and enhance neutrophil and platelet recovery following chemotherapy and bone marrow transplantation (BMT). These results suggest that PIXY321 elicits the biological effects of both its component cytokines and represents a novel means of delivering two independent but interactive cytokines in combination." @default.
• W1970369110 created "2016-06-24" @default.
• W1970369110 creator A5009177808 @default.
• W1970369110 date "1994-01-01" @default.
• W1970369110 modified "2023-10-16" @default.
• W1970369110 title "PIXY321 (GM‐CSF/IL‐3 fusion protein): Biology and early clinical development" @default.
• W1970369110 cites W1890652092 @default.
• W1970369110 cites W1973034088 @default.
• W1970369110 cites W1985136922 @default.
• W1970369110 cites W2019905045 @default.
• W1970369110 cites W2057425835 @default.
• W1970369110 cites W2068382284 @default.
• W1970369110 cites W2092740495 @default.
• W1970369110 cites W2123472995 @default.
• W1970369110 cites W2143098122 @default.
• W1970369110 cites W2147530468 @default.
• W1970369110 cites W2150008544 @default.
• W1970369110 cites W2224858876 @default.
• W1970369110 cites W2247320038 @default.
• W1970369110 cites W2261504327 @default.
• W1970369110 cites W2341557816 @default.
• W1970369110 cites W2409062727 @default.
• W1970369110 cites W2419306110 @default.
• W1970369110 cites W257664027 @default.
• W1970369110 cites W2593892363 @default.
• W1970369110 cites W2607721102 @default.
• W1970369110 cites W36713696 @default.
• W1970369110 doi "https://doi.org/10.1002/stem.5530120302" @default.
• W1970369110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8075592" @default.
• W1970369110 hasPublicationYear "1994" @default.
• W1970369110 type Work @default.
• W1970369110 sameAs 1970369110 @default.
• W1970369110 citedByCount "23" @default.
• W1970369110 countsByYear W19703691102013 @default.
• W1970369110 countsByYear W19703691102017 @default.
• W1970369110 crossrefType "journal-article" @default.
• W1970369110 hasAuthorship W1970369110A5009177808 @default.
• W1970369110 hasConcept C104317684 @default.
• W1970369110 hasConcept C109159458 @default.
• W1970369110 hasConcept C123894998 @default.
• W1970369110 hasConcept C129374314 @default.
• W1970369110 hasConcept C131665280 @default.
• W1970369110 hasConcept C150903083 @default.
• W1970369110 hasConcept C170493617 @default.
• W1970369110 hasConcept C201750760 @default.
• W1970369110 hasConcept C2022786 @default.
• W1970369110 hasConcept C203014093 @default.
• W1970369110 hasConcept C207001950 @default.
• W1970369110 hasConcept C2776090121 @default.
• W1970369110 hasConcept C2777478134 @default.
• W1970369110 hasConcept C2778690821 @default.
• W1970369110 hasConcept C2779282312 @default.
• W1970369110 hasConcept C2780007613 @default.
• W1970369110 hasConcept C28328180 @default.
• W1970369110 hasConcept C40767141 @default.
• W1970369110 hasConcept C502942594 @default.
• W1970369110 hasConcept C55493867 @default.
• W1970369110 hasConcept C86803240 @default.
• W1970369110 hasConcept C8891405 @default.
• W1970369110 hasConcept C95444343 @default.
• W1970369110 hasConceptScore W1970369110C104317684 @default.
• W1970369110 hasConceptScore W1970369110C109159458 @default.
• W1970369110 hasConceptScore W1970369110C123894998 @default.
• W1970369110 hasConceptScore W1970369110C129374314 @default.
• W1970369110 hasConceptScore W1970369110C131665280 @default.
• W1970369110 hasConceptScore W1970369110C150903083 @default.
• W1970369110 hasConceptScore W1970369110C170493617 @default.
• W1970369110 hasConceptScore W1970369110C201750760 @default.
• W1970369110 hasConceptScore W1970369110C2022786 @default.
• W1970369110 hasConceptScore W1970369110C203014093 @default.
• W1970369110 hasConceptScore W1970369110C207001950 @default.
• W1970369110 hasConceptScore W1970369110C2776090121 @default.
• W1970369110 hasConceptScore W1970369110C2777478134 @default.
• W1970369110 hasConceptScore W1970369110C2778690821 @default.
• W1970369110 hasConceptScore W1970369110C2779282312 @default.
• W1970369110 hasConceptScore W1970369110C2780007613 @default.
• W1970369110 hasConceptScore W1970369110C28328180 @default.
• W1970369110 hasConceptScore W1970369110C40767141 @default.
• W1970369110 hasConceptScore W1970369110C502942594 @default.
• W1970369110 hasConceptScore W1970369110C55493867 @default.
• W1970369110 hasConceptScore W1970369110C86803240 @default.
• W1970369110 hasConceptScore W1970369110C8891405 @default.
• W1970369110 hasConceptScore W1970369110C95444343 @default.
• W1970369110 hasIssue "3" @default.
• W1970369110 hasLocation W19703691101 @default.
• W1970369110 hasLocation W19703691102 @default.
• W1970369110 hasOpenAccess W1970369110 @default.
• W1970369110 hasPrimaryLocation W19703691101 @default.
• W1970369110 hasRelatedWork W1976841286 @default.
• W1970369110 hasRelatedWork W1977841877 @default.
• W1970369110 hasRelatedWork W2011399447 @default.
• W1970369110 hasRelatedWork W2094330048 @default.
• W1970369110 hasRelatedWork W2432867267 @default.
• W1970369110 hasRelatedWork W246905007 @default.
• W1970369110 hasRelatedWork W292442544 @default.
• W1970369110 hasRelatedWork W4238573699 @default.
• W1970369110 hasRelatedWork W4249084103 @default.
• W1970369110 hasRelatedWork W2150978978 @default.

• next