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• W1970396572 endingPage "124" @default.
• W1970396572 startingPage "111" @default.
• W1970396572 abstract "Noninvasive prenatal testing (NIPT) for fetal aneuploidies using cell-free fetal DNA in maternal plasma has revolutionized the field of prenatal care and methods using massively parallel sequencing are now being implemented almost worldwide. Substantial progress has been made from initially testing for (an)euploidies of chromosomes 13, 18 and 21, to testing for sex chromosome (an)euploidies, additional autosomal aneuploidies as well as partial deletions and duplications genome-wide. Although NIPT is associated with significantly reduced risks for the fetus in comparison to existing invasive prenatal diagnostic methods, it presents several implementation challenges. Here, we review key issues potentially influencing NIPT and illustrate them using both data from literature and in-house data." @default.
• W1970396572 created "2016-06-24" @default.
• W1970396572 creator A5031526655 @default.
• W1970396572 creator A5070217324 @default.
• W1970396572 creator A5087964773 @default.
• W1970396572 creator A5089544646 @default.
• W1970396572 date "2014-10-27" @default.
• W1970396572 modified "2023-10-16" @default.
• W1970396572 title "Implementation of whole genome massively parallel sequencing for noninvasive prenatal testing in laboratories" @default.
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