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• W1970403731 abstract "<i>Background:</i> The surfactant proteins SP-A and SP-D, components of the innate immune system, are involved in host defence. <i>Objective:</i> We tested the hypothesis that ovalbumin (OVA) challenge leads to an upregulation of both proteins in alveolar epithelial type II cells (AEII) and Clara cells and to an enhanced uptake by macrophages. <i>Methods:</i> After sensitization with OVA and heat-killed <i>Bordetella pertussis</i> challenge followed intratracheally with 0.5% OVA on day 13. One day after challenge lung tissue and bronchoalveolar lavage fluid (BALF) of sensitized NaCl- and OVA-challenged Brown Norway rats were compared with home cage controls using qRt-PCR, Western blot and immunohistochemistry. <i>Results:</i> After OVA challenge (1) eosinophils increased significantly in the BALF, (2) the total amount of SP-A and SP-D was significantly increased in lung tissue, (3) the amount of SP-A was significantly and the amount of SP-D was remarkably elevated in BALF, and (4) the levels of SP-A and SP-D mRNA in lung tissue were significantly elevated. Using quantitative immunohistochemistry, we found (5) significantly higher surface fractions of SP-A- and SP-D-labelled AEII, (6) no differences in the surface fractions of SP-A- and SP-D-labelled bronchial Clara cells, and (7) a significantly increased cell density of unlabelled and SP-A-labelled macrophages. <i>Conclusions:</i> Thus, combining molecular biological and histological methods we suggest that after OVA challenge (1) AEII but not Clara cells show a significantly higher expression of SP-A and SP-D leading also to higher amounts of both SPs in BALF and (2) macrophages gather predominantly SP-A." @default.
• W1970403731 created "2016-06-24" @default.
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• W1970403731 date "2008-09-19" @default.
• W1970403731 modified "2023-09-23" @default.
• W1970403731 title "Increased Surfactant Protein A and D Expression in Acute Ovalbumin-Induced Allergic Airway Inflammation in Brown Norway Rats" @default.
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• W1970403731 doi "https://doi.org/10.1159/000155742" @default.
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