Matches in SemOpenAlex for { <https://semopenalex.org/work/W1970409619> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1970409619 endingPage "38" @default.
- W1970409619 startingPage "31" @default.
- W1970409619 abstract "Acridines are nucleic acid intercalating compounds with properties relating to the complexity of their structure. Tetrahydroaminoacridine (tacrine, Cognex), a simple acridine, is a reversible inhibitor of cholinesterase activity available for the symptomatic treatment of Alzheimer's disease. Tacrine therapy causes sporadic elevations of aminotransferases in humans, and tacrine alters protein synthesis and ribosomal structure under short-term in vitro exposures in isolated hepatocytes from humans and other species. There is no clear relationship between transaminase elevation and liver damage in humans, and prolonged drug exposure to animals does not result in hepatic insult. Subcellular alterations have been described in isolated human and rodent hepatocytes, including degranulation and vesiculation of the endoplasmic reticulum (ER), aggregation of electron-dense structures within the ER, altered nuclei and nucleoli and detrimental structural and functional effects to mitochondria. Whether these changes in hepatocyte morphology and function are unique to tacrine or not is unknown, as human hepatocytes exposed to more complex acridines have not been characterized. In this study, we extended the results of in vitro studies with tacrine to acridine orange, 9-aminoacridine, quinacrine and proflavin. In primary human hepatocytes, these compounds caused a similar reduction of mitochondrial membrane potential with parallel ultrastructural changes. The 1-hydroxy and 7-hydroxy tacrine metabolites, acridine hydrochloride and acridine 9-carboxylic acid, and the non-acridine cholinesterase inhibitor eserine, did not induce characteristic subcellular ER changes but damaged mitochondria structure, reduced mitochondrial membrane potential and were cytotoxic. These data indicate that the tacrine-like subcellular changes in hepatocytes are reproducible with other acridines and cause mitochondrial dysfunction in human hepatocytes." @default.
- W1970409619 created "2016-06-24" @default.
- W1970409619 creator A5055315264 @default.
- W1970409619 creator A5073021926 @default.
- W1970409619 date "1999-01-01" @default.
- W1970409619 modified "2023-10-16" @default.
- W1970409619 title "Acridine-induced subcellular and functional changes in isolated human hepatocytesin vitro" @default.
- W1970409619 cites W1968393987 @default.
- W1970409619 cites W1981384318 @default.
- W1970409619 cites W1985035834 @default.
- W1970409619 cites W1994414156 @default.
- W1970409619 cites W2000451262 @default.
- W1970409619 cites W2000837493 @default.
- W1970409619 cites W2004576225 @default.
- W1970409619 cites W2005575618 @default.
- W1970409619 cites W2021742076 @default.
- W1970409619 cites W2033256212 @default.
- W1970409619 cites W2055926189 @default.
- W1970409619 cites W2062229879 @default.
- W1970409619 cites W2086147461 @default.
- W1970409619 cites W2126095231 @default.
- W1970409619 cites W2141047057 @default.
- W1970409619 cites W2150611233 @default.
- W1970409619 cites W2342517577 @default.
- W1970409619 doi "https://doi.org/10.1002/(sici)1099-1263(199901/02)19:1<31::aid-jat535>3.0.co;2-6" @default.
- W1970409619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9989475" @default.
- W1970409619 hasPublicationYear "1999" @default.
- W1970409619 type Work @default.
- W1970409619 sameAs 1970409619 @default.
- W1970409619 citedByCount "13" @default.
- W1970409619 countsByYear W19704096192017 @default.
- W1970409619 countsByYear W19704096192019 @default.
- W1970409619 countsByYear W19704096192023 @default.
- W1970409619 crossrefType "journal-article" @default.
- W1970409619 hasAuthorship W1970409619A5055315264 @default.
- W1970409619 hasAuthorship W1970409619A5073021926 @default.
- W1970409619 hasConcept C158617107 @default.
- W1970409619 hasConcept C178790620 @default.
- W1970409619 hasConcept C181199279 @default.
- W1970409619 hasConcept C185592680 @default.
- W1970409619 hasConcept C190283241 @default.
- W1970409619 hasConcept C202751555 @default.
- W1970409619 hasConcept C2776924795 @default.
- W1970409619 hasConcept C2778816929 @default.
- W1970409619 hasConcept C2779046751 @default.
- W1970409619 hasConcept C2779102032 @default.
- W1970409619 hasConcept C28859421 @default.
- W1970409619 hasConcept C55493867 @default.
- W1970409619 hasConcept C86803240 @default.
- W1970409619 hasConceptScore W1970409619C158617107 @default.
- W1970409619 hasConceptScore W1970409619C178790620 @default.
- W1970409619 hasConceptScore W1970409619C181199279 @default.
- W1970409619 hasConceptScore W1970409619C185592680 @default.
- W1970409619 hasConceptScore W1970409619C190283241 @default.
- W1970409619 hasConceptScore W1970409619C202751555 @default.
- W1970409619 hasConceptScore W1970409619C2776924795 @default.
- W1970409619 hasConceptScore W1970409619C2778816929 @default.
- W1970409619 hasConceptScore W1970409619C2779046751 @default.
- W1970409619 hasConceptScore W1970409619C2779102032 @default.
- W1970409619 hasConceptScore W1970409619C28859421 @default.
- W1970409619 hasConceptScore W1970409619C55493867 @default.
- W1970409619 hasConceptScore W1970409619C86803240 @default.
- W1970409619 hasIssue "1" @default.
- W1970409619 hasLocation W19704096191 @default.
- W1970409619 hasLocation W19704096192 @default.
- W1970409619 hasOpenAccess W1970409619 @default.
- W1970409619 hasPrimaryLocation W19704096191 @default.
- W1970409619 hasRelatedWork W1963631517 @default.
- W1970409619 hasRelatedWork W1969366112 @default.
- W1970409619 hasRelatedWork W1970409619 @default.
- W1970409619 hasRelatedWork W1995844264 @default.
- W1970409619 hasRelatedWork W2085652794 @default.
- W1970409619 hasRelatedWork W2088081405 @default.
- W1970409619 hasRelatedWork W2119927689 @default.
- W1970409619 hasRelatedWork W2409800174 @default.
- W1970409619 hasRelatedWork W3046943626 @default.
- W1970409619 hasRelatedWork W3199336162 @default.
- W1970409619 hasVolume "19" @default.
- W1970409619 isParatext "false" @default.
- W1970409619 isRetracted "false" @default.
- W1970409619 magId "1970409619" @default.
- W1970409619 workType "article" @default.