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- W1970409957 abstract "The positive association between body weight and bone density has been established in numerous laboratory and clinical studies. Apart from the direct effect of soft tissue mass on bone through skeletal loading, a number of cytokines and hormones contribute to the positive association between adipose and bone tissue, acting either locally in sites where cells of the two tissues are adjacent to each other or systemically through the circulation. The current review describes the effects of such local and systemic factors on bone physiology. One class of factors are the adipocyte-secreted peptides (adipokines), which affect bone turnover through a combination of direct effects in bone cells and indirect mechanisms mediated by the central nervous system. Another source of hormones that contribute to the coupling between fat and bone tissue are beta cells of the pancreas. Insulin, amylin and preptin are co-secreted from pancreatic beta cells in response to increased glucose levels after feeding, and are also found in high circulating levels in obesity. A number of peptide hormones secreted from the gastrointestinal tract in response to feeding affect both fat and bone cells and thus can also act as mediators of the association between the two tissues. The current review focuses on results of laboratory studies investigating possible mechanism involved in the positive association between fat mass and bone mass." @default.
- W1970409957 created "2016-06-24" @default.
- W1970409957 creator A5023711994 @default.
- W1970409957 creator A5087059388 @default.
- W1970409957 date "2014-05-09" @default.
- W1970409957 modified "2023-10-13" @default.
- W1970409957 title "Cytokines and Hormones That Contribute to the Positive Association between Fat and Bone" @default.
- W1970409957 cites W1501939485 @default.
- W1970409957 cites W1515924291 @default.
- W1970409957 cites W1572510157 @default.
- W1970409957 cites W1607536434 @default.
- W1970409957 cites W1631449371 @default.
- W1970409957 cites W1637971961 @default.
- W1970409957 cites W1909242889 @default.
- W1970409957 cites W1923346998 @default.
- W1970409957 cites W1963690512 @default.
- W1970409957 cites W1965774172 @default.
- W1970409957 cites W1965915581 @default.
- W1970409957 cites W1967734933 @default.
- W1970409957 cites W1971193583 @default.
- W1970409957 cites W1971743791 @default.
- W1970409957 cites W1972328688 @default.
- W1970409957 cites W1974503725 @default.
- W1970409957 cites W1974663313 @default.
- W1970409957 cites W1976715250 @default.
- W1970409957 cites W1979128803 @default.
- W1970409957 cites W1980740451 @default.
- W1970409957 cites W1980766714 @default.
- W1970409957 cites W1981261500 @default.
- W1970409957 cites W1984384276 @default.
- W1970409957 cites W1984833283 @default.
- W1970409957 cites W1986550196 @default.
- W1970409957 cites W1986880059 @default.
- W1970409957 cites W1987012320 @default.
- W1970409957 cites W1987081198 @default.
- W1970409957 cites W1987164352 @default.
- W1970409957 cites W1989962564 @default.
- W1970409957 cites W1990357124 @default.
- W1970409957 cites W1991369958 @default.
- W1970409957 cites W1992535385 @default.
- W1970409957 cites W1992673132 @default.
- W1970409957 cites W1992826431 @default.
- W1970409957 cites W1993580279 @default.
- W1970409957 cites W1996104146 @default.
- W1970409957 cites W1996462314 @default.
- W1970409957 cites W1996491999 @default.
- W1970409957 cites W1996713062 @default.
- W1970409957 cites W1998927491 @default.
- W1970409957 cites W2003633907 @default.
- W1970409957 cites W2003751765 @default.
- W1970409957 cites W2004021898 @default.
- W1970409957 cites W2005840341 @default.
- W1970409957 cites W2006746776 @default.
- W1970409957 cites W2008507667 @default.
- W1970409957 cites W2009425929 @default.
- W1970409957 cites W2010047567 @default.
- W1970409957 cites W2010167659 @default.
- W1970409957 cites W2010308446 @default.
- W1970409957 cites W2011368359 @default.
- W1970409957 cites W2013339414 @default.
- W1970409957 cites W2017064286 @default.
- W1970409957 cites W2017710244 @default.
- W1970409957 cites W2019536816 @default.
- W1970409957 cites W2020090438 @default.
- W1970409957 cites W2031207391 @default.
- W1970409957 cites W2035216298 @default.
- W1970409957 cites W2038426107 @default.
- W1970409957 cites W2039998322 @default.
- W1970409957 cites W2040319473 @default.
- W1970409957 cites W2040396816 @default.
- W1970409957 cites W2042007700 @default.
- W1970409957 cites W2043310079 @default.
- W1970409957 cites W2043397155 @default.
- W1970409957 cites W2047245896 @default.
- W1970409957 cites W2047761422 @default.
- W1970409957 cites W2049409177 @default.
- W1970409957 cites W2050005341 @default.
- W1970409957 cites W2050080529 @default.
- W1970409957 cites W2062255368 @default.
- W1970409957 cites W2062628516 @default.
- W1970409957 cites W2066219800 @default.
- W1970409957 cites W2070393006 @default.
- W1970409957 cites W2076892807 @default.
- W1970409957 cites W2079538512 @default.
- W1970409957 cites W2082735845 @default.
- W1970409957 cites W2084398491 @default.
- W1970409957 cites W2084590092 @default.
- W1970409957 cites W2084885557 @default.
- W1970409957 cites W2085686177 @default.
- W1970409957 cites W2087404413 @default.
- W1970409957 cites W2091309106 @default.
- W1970409957 cites W2091403268 @default.
- W1970409957 cites W2096780937 @default.
- W1970409957 cites W2103318165 @default.
- W1970409957 cites W2108642017 @default.
- W1970409957 cites W2110312893 @default.
- W1970409957 cites W2113229940 @default.
- W1970409957 cites W2121827210 @default.
- W1970409957 cites W2126412210 @default.
- W1970409957 cites W2127987301 @default.